Current Status of HbA1c Biosensors

Glycated hemoglobin (HbA1c) is formed via non-enzymatic glycosylation reactions at the α-amino group of βVal1 residues in the tetrameric Hb, and it can reflect the ambient glycemic level over the past two to three months. A variety of HbA1c detection methods, including chromatography, immunoassay, e...

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Bibliographic Details
Published in:Sensors (Basel, Switzerland) Switzerland), 2017-08, Vol.17 (8), p.1798
Main Authors: Lin, Hua, Yi, Jun
Format: Article
Language:English
Subjects:
antibody
biosensor
Biosensors
boronic acid
fructosyl valine
Glucose
glycated hemoglobin (HbA1c)
Hemoglobin
Immunoassay
Laboratories
Review
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Summary:Glycated hemoglobin (HbA1c) is formed via non-enzymatic glycosylation reactions at the α-amino group of βVal1 residues in the tetrameric Hb, and it can reflect the ambient glycemic level over the past two to three months. A variety of HbA1c detection methods, including chromatography, immunoassay, enzymatic measurement, electrochemical sensor and capillary electrophoresis have been developed and used in research laboratories and in clinics as well. In this review, we summarize the current status of HbA1c biosensors based on the recognition of the sugar moiety on the protein and also their applications in the whole blood sample measurements.
ISSN:1424-8220
1424-8220
DOI:10.3390/s17081798