Lumazine peptides from the marine-derived fungus Aspergillus terreus

Terrelumamides A (1) and B (2), two new lumazine-containing peptides, were isolated from the culture broth of the marine-derived fungus Aspergillus terreus. From the results of combined spectroscopic and chemical analyses, the structures of these compounds were determined to be linear assemblies of...

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Bibliographic Details
Published in:Marine drugs 2015-03, Vol.13 (3), p.1290-1303
Main Authors: You, Minjung, Liao, Lijuan, Hong, Soo Hyun, Park, Wanki, Kwon, Dah In, Lee, Jeeyeon, Noh, Minsoo, Oh, Dong-Chan, Oh, Ki-Bong, Shin, Jongheon
Format: Article
Language:English
Subjects:
Adipogenesis - drug effects
Aspergillus - chemistry
Aspergillus terreus
DNA - metabolism
Fluorescence
Humans
insulin sensitivity
lumazine
Marine
Mesenchymal Stromal Cells - drug effects
Mesenchymal Stromal Cells - metabolism
peptide
Peptides - chemistry
Peptides - isolation & purification
Peptides - pharmacology
Pteridines - chemistry
Pteridines - isolation & purification
Pteridines - pharmacology
Spectrum Analysis
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Summary:Terrelumamides A (1) and B (2), two new lumazine-containing peptides, were isolated from the culture broth of the marine-derived fungus Aspergillus terreus. From the results of combined spectroscopic and chemical analyses, the structures of these compounds were determined to be linear assemblies of 1-methyllumazine-6-carboxylic acid, an amino acid residue and anthranilic acid methyl ester connected by peptide bonds. These new compounds exhibited pharmacological activity by improving insulin sensitivity, which was evaluated in an adipogenesis model using human bone marrow mesenchymal stem cells. In addition, the compounds exhibited fluorescence changes upon binding to DNA, demonstrating their potential applications to DNA sequence recognition.
ISSN:1660-3397
1660-3397
DOI:10.3390/md13031290