Predictors of cardiac arrhythmic events in non coronary artery disease patients

Arrhythmic sudden cardiac death (SCD) represents a major worldwide public health problem accounting for 15-20% of deaths. Risk stratification to identify patients at risk of SCD is crucial in order to implement preventive measures in the general population. Several biomarkers have been tested explor...

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Bibliographic Details
Published in:BMC cardiovascular disorders 2019-05, Vol.19 (1), p.104-104, Article 104
Main Authors: Balla, C, Vitali, F, Brieda, A, Gualandi, F, Ferlini, A, Bertini, M, Ferrari, R
Format: Article
Language:English
Subjects:
Accounting
Arrhythmia
Arrhythmias, Cardiac - blood
Arrhythmias, Cardiac - etiology
Arrhythmias, Cardiac - genetics
Arrhythmias, Cardiac - mortality
Biological markers
Biomarkers
Cardiac arrhythmia
Cardiac patients
Cardiomyopathy
Cardiovascular disease
Coronary artery
Coronary artery disease
Coronary heart disease
Coronary vessels
Death
Death, Sudden, Cardiac - etiology
Defibrillators
Development and progression
Diagnosis
Electrocardiography
Etiology
Fatty acids
Fatty Acids - blood
Genetic aspects
Genetic Markers
Genetic Predisposition to Disease
Genetic research
Genetic testing
Genetic variation
Genomes
Gonadal Steroid Hormones - blood
Health aspects
Health risk assessment
Heart
Heart attacks
Heart diseases
Hormones
Humans
Inflammation Mediators - blood
MicroRNA
MicroRNAs - genetics
miRNA
Molecular Diagnostic Techniques
Natriuretic Peptide, Brain - blood
NAV1.5 Voltage-Gated Sodium Channel - genetics
Peptides
Phenotype
Population
Predictive Value of Tests
Prevention
Public health
Review
Risk Factors
Sex hormones
Sudden cardiac death
Ventricle
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Description
Summary:Arrhythmic sudden cardiac death (SCD) represents a major worldwide public health problem accounting for 15-20% of deaths. Risk stratification to identify patients at risk of SCD is crucial in order to implement preventive measures in the general population. Several biomarkers have been tested exploring different pathophysiological mechanisms of cardiac conditions. Conflicting results have been described limiting so far their use in clinical practice. The use of new biomarkers such as microRNAs and sex hormones and the emerging role of genetic on risk prediction of SCD is a current research topic showing promising results.This review outlines the role of plasma biomarkers to predict ventricular arrhythmias and SCD in non coronary artery disease with a special focus on their relationship with the genetic biomarkers.
ISSN:1471-2261
1471-2261
DOI:10.1186/s12872-019-1083-6