Obstruction of Small Arterioles in Patients with Critical Limb Ischemia due to Partial Endothelial-to-Mesenchymal Transition

Critical limb ischemia (CLI) is a hazardous manifestation of atherosclerosis and treatment failure is common. Abnormalities in the arterioles might underlie this failure but the cellular pathobiology of microvessels in CLI is poorly understood. We analyzed 349 intramuscular arterioles in lower limb...

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Bibliographic Details
Published in:iScience 2020-06, Vol.23 (6), p.101251-101251, Article 101251
Main Authors: Chevalier, Jacqueline, Yin, Hao, Arpino, John-Michael, O'Neil, Caroline, Nong, Zengxuan, Gilmore, Kevin J., Lee, Jason J., Prescott, Emma, Hewak, Matthew, Rice, Charles L., Dubois, Luc, Power, Adam H., Hamilton, Douglas W., Pickering, J. Geoffrey
Format: Article
Language:English
Subjects:
Clinical Finding
Human Specimen
Pathophysiology
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Summary:Critical limb ischemia (CLI) is a hazardous manifestation of atherosclerosis and treatment failure is common. Abnormalities in the arterioles might underlie this failure but the cellular pathobiology of microvessels in CLI is poorly understood. We analyzed 349 intramuscular arterioles in lower limb specimens from individuals with and without CLI. Arteriolar densities were 1.8-fold higher in CLI muscles. However, 33% of small (
ISSN:2589-0042
2589-0042
DOI:10.1016/j.isci.2020.101251