TNFA -308G>A and IL10 -1082A>G polymorphisms seem to be predictive biomarkers of chronic HCV infection

• Published in: BMC infectious diseases 2021-11, Vol.21 (1), p.1133-1133, Article 1133
• Main Authors: Santiago, Angélica Menezes, da Silva Graça Amoras, Ednelza, Queiroz, Maria Alice Freitas, da Silva Conde, Simone Regina Souza, Cayres-Vallinoto, Izaura Maria Vieira, Ishak, Ricardo, Vallinoto, Antonio Carlos Rosário
• Format: Article
• Language: English
• Subjects: Antigens; Biomarkers; Biopsy; Chronic infection; Cytokines; Fibrosis; Gene polymorphism; Genotype; HCV; Hepacivirus; Hepatitis; Hepatitis B; Hepatitis C; Hepatitis C, Chronic - genetics; HIV; Human immunodeficiency virus; Humans; Immune system; Infections; Infectious diseases; Inflammation; Interleukin 1; Interleukin 10; Interleukin-10 - genetics; Investigations; Liver cancer; Medical records; Polymorphism; Polymorphism, Genetic; Polymorphism, Single Nucleotide; Software; TNF-alpha; Tumor Necrosis Factor-alpha; Tumor necrosis factor-TNF
• ISSN: 1471-2334; 1471-2334
• DOI: 10.1186/s12879-021-06835-9

Genetic changes may induce dysregulated cytokine production and affect the progression of the chronic disease caused by the hepacivirus C (HCV) because the balance of pro- and anti-inflammatory cytokines determines the outcome of infection. This study evaluated the TNFA -308G>A and IL10 -1082A>G polymorphisms in the susceptibility and progress of chronic hepatitis C. The study included 101 samples from patients with chronic hepatitis C and 300 samples from healthy donors. Polymorphisms were typed by real-time PCR and were analyzed for associations with histopathological parameters (according to METAVIR classification) and HCV viral load. The polymorphic genotype for the TNFA -308G>A variant was not present in the group of patients with chronic hepatitis C and its absence could be associated with protection against HCV infection (p = 0.0477). Patients with the polymorphic genotype of the IL10 -1082A>G polymorphism had higher HCV viral load than wild-type patients (p = 0.0428). Neither polymorphism was associated with different levels of necroinflammatory activity or fibrosis scores. Our results suggest the polymorphic genotype at TNFA -308G>A as protective against chronic HCV infection, and the polymorphic genotype at the IL10 -1082A>G variant associated with higher HCV viral load. Further studies must be performed in order to confirm these associations.