Immunomodulatory Role of Capsular Polysaccharides Constituents of Cryptococcus neoformans

Cryptococcosis is a systemic fungal infection caused by . In immunocompetent patients, cryptococcal infection is often confined to the lungs. In immunocompromised individuals, may cause life-threatening illness, either from novel exposure or through reactivation of a previously acquired latent infec...

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Bibliographic Details
Published in:Frontiers in medicine 2019-06, Vol.6, p.129-129
Main Authors: Decote-Ricardo, Debora, LaRocque-de-Freitas, Isabel Ferreira, Rocha, Juliana Dutra B, Nascimento, Danielle O, Nunes, Marise P, Morrot, Alexandre, Freire-de-Lima, Leonardo, Previato, Jose Osvaldo, Mendonça-Previato, Lucia, Freire-de-Lima, Celio Geraldo
Format: Article
Language:English
Subjects:
Cryptococcus neoformans
galactoxylomannan (GalXM)
glucuronoxylomannan (GXM)
immuno evasion
immunomodulation
Medicine
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Summary:Cryptococcosis is a systemic fungal infection caused by . In immunocompetent patients, cryptococcal infection is often confined to the lungs. In immunocompromised individuals, may cause life-threatening illness, either from novel exposure or through reactivation of a previously acquired latent infection. For example, cryptococcal meningitis is a severe clinical disease that can manifest in people that are immunocompromised due to AIDS. The major constituents of the polysaccharide capsule, glucuronoxylomannan (GXM), and galactoxylomannan (GalXM), also known as glucuronoxylomanogalactan (GXMGal), are considered the primary virulence factors of . Despite the predominance of GXM in the polysaccharide capsule, GalXM has more robust immunomodulatory effects on host cellular immunity. This review summarizes current knowledge regarding host- interactions and the role of capsular polysaccharides in host immunomodulation. Future studies will likely facilitate a better understanding of the mechanisms involved in antigenic recognition and host immune response to and lead to the development of new therapeutic pathways for cryptococcal infection.
ISSN:2296-858X
2296-858X
DOI:10.3389/fmed.2019.00129