Gold nanoparticle-mediated photothermal therapy guidance with multi-wavelength photomagnetic imaging

• Published in: Photodiagnosis and photodynamic therapy 2024-02, Vol.45, p.103956, Article 103956
• Main Authors: Nouizi, Farouk, Algarawi, Maha, Erkol, Hakan, Gulsen, Gultekin
• Format: Article
• Language: English
• Subjects: Gold nanoparticles; Magnetic resonance thermometry; Multi-wavelength imaging; Photo-magnetic imaging; Photothermal agents; Photothermal therapy
• ISSN: 1572-1000; 1873-1597; 1873-1597
• DOI: 10.1016/j.pdpdt.2023.103956

•AuNPs boost selectivity and reduce damage to surrounding healthy tissues during PTT.•Photomagnetic imaging (PMI) can be used in tandem to guide the PTT.•Multi-wavelength PMI can reveal AuNP concentration based on their absorption spectra.•The AuNP concentration info can help to model the temperature increase in tumors.•Modelling can provide laser illumination power, duration, and wavelength for PTT. Difficulty in heating tumors with high spatial selectivity while protecting surrounding healthy tissues from thermal harm is a challenge for cancer photothermal treatment (PTT). To mitigate this problem, PTT mediated by photothermal agents (PTAs) has been established as a potential therapeutic technique to boost selectivity and reduce damage to surrounding healthy tissues. Various gold nanoparticles (AuNP) have been effectively utilized as PTAs, mainly using strategies to target cancerous tissue and increase selective thermal damage. Meanwhile, imaging can be used in tandem to monitor the AuNP distribution and guide the PTT. Mainly, the parameters impacting the induced temperature can be determined using simulation tools before treatment for effective PTT. However, accurate simulations can only be performed if the amount of AuNPs accumulated in the tumor is known. This study introduces Photo-Magnetic Imaging (PMI), which can appropriately recover the AuNP concentration to guide the PTT. Using multi-wavelength measurements, PMI can provide AuNP concentration based on their distinct absorption spectra. Tissue-simulating phantom studies are conducted to demonstrate the potential of PMI in recovering AuNP concentration for PTT planning. The recovered AuNP concentration is used to model the temperature increase accurately in a small inclusion representing tumor using a multiphysics solver that takes into account the light propagation and heat diffusion in turbid media.