Primary renal leukaemia in a young adult male as an extramedullary presentation of T cell acute lymphoblastic leukaemia

Primary renal involvement by T lymphoblasts is rare among adults with T acute lymphoblastic leukaemia. We report a 28‐year‐old man presenting with acute renal failure due to infiltration by T lymphoblasts and his response to paediatric‐inspired modified BFM‐90 protocol. The patient achieved an initi...

Full description

Saved in:
Bibliographic Details
Published in:EJHaem 2024-02, Vol.5 (1), p.251-255
Main Authors: Jain, Punit, Jain, Poonam, Ohgami, Robert S., Pawar, Veena, Sehgal, Kunal, Chaudhari, Pradnya, Nikalji, Ravindra, Singh, Tejinder, Khandelwal, Vipin, Khare, Sanjay, Lokhande, Vaishali, Haridas, Ashwathy, Jessani, Laxman, Khandelwal, Kanika
Format: Article
Language:English
Subjects:
Acute lymphoblastic leukemia
acute renal failure in T‐ALL
Adults
Biopsy
Bone marrow
Central nervous system
Chemotherapy
Cytomegalovirus
extramedullary manifestations in T‐ALL
Kidney transplantation
Kidneys
Leukemia
Lymphoblasts
Lymphocytes T
Medical prognosis
Modified BFM‐90 protocol
Mutation
Nervous system
Neutrophils
Patients
Pediatrics
Remission
Remission (Medicine)
Renal failure
Sepsis
Skin
Stem cells
T cell acute lymphoblastic leukaemia
Transplants & implants
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Primary renal involvement by T lymphoblasts is rare among adults with T acute lymphoblastic leukaemia. We report a 28‐year‐old man presenting with acute renal failure due to infiltration by T lymphoblasts and his response to paediatric‐inspired modified BFM‐90 protocol. The patient achieved an initial complete remission (CR) but developed central nervous system relapse. He achieved CR2 with cranial irradiation and intrathecal chemotherapy. He underwent a haploidentical transplant in CR2 and remains in remission post‐transplant day 330. An early kidney biopsy helped confirm the diagnosis. Such presentations remain responsive to modified BFM‐90. An early allotransplant in CR2 remains the standard of care.
ISSN:2688-6146
2688-6146
DOI:10.1002/jha2.820