Pharmacological Activities of Lonicerae japonicae flos and Its Derivative-"Chrysoeriol" in Skin Diseases

• Published in: Molecules (Basel, Switzerland) Switzerland), 2024-04, Vol.29 (9), p.1972
• Main Authors: Law, Siu Kan, Wu, Xiao Xiao, Jiang, Zhou, Tong, Christy Wing Sum, Chow, Wesley Yeuk Lung, Au, Dawn Ching Tung
• Format: Article
• Language: English
• Subjects: Acne; Animals; Antioxidants; Chinese medicine; chrysoeriol; cutaneous route; Cytokines; Drugs, Chinese Herbal - chemistry; Drugs, Chinese Herbal - pharmacology; Eczema; Flavonoids; Flowers - chemistry; Humans; Inflammation; Lonicera - chemistry; Lonicerae japonicae flos; pharmacokinetic and pharmacodynamic activities; pharmacological function; Plant Extracts - chemistry; Plant Extracts - pharmacology; Psoriasis; Skin diseases; Skin Diseases - drug therapy; Toxins
• ISSN: 1420-3049; 1420-3049
• DOI: 10.3390/molecules29091972

Chrysoeriol is an active ingredient derived from the Chinese medicinal herb (CMH) " " in the dried flower bud or bloomed flower of Thunberg. Dermatoses are the most common diseases in humans, including eczema, acne, psoriasis, moles, and fungal infections, which are temporary or permanent and may be painless or painful. Topical corticosteroids are widely used in Western medicine, but there are some side effects when it is continuously and regularly utilized in a large dosage. Chrysoeriol is a natural active ingredient, nontoxic, and without any adverse reactions in the treatment of dermatological conditions. Nine electronic databases were searched, including WanFang Data, PubMed, Science Direct, Scopus, Web of Science, Springer Link, SciFinder, and China National Knowledge Infrastructure (CNKI), without regard to language constraints. The pharmacological activities of chrysoeriol from to fight against skin diseases were explained and evaluated through the literature review of either in vitro or in vivo studies. Chrysoeriol decreased the mRNA levels of proinflammatory cytokines IL-6, IL-1β, and TNF-α. These were transcriptionally regulated by NF-κB and STAT3 to combat skin inflammation. It also showed promising actions in treating many skin ailments including wound healing, depigmentation, photoprotection, and antiaging. The cutaneous route is the best delivery approach to chrysoeriol across the skin barrier. However, toxicity, dosage, and safety assessments of chrysoeriol in a formulation or nanochrysoeriol on the human epidermis for application in skin diseases must be further investigated.