A study of autoencoders as a feature extraction technique for spike sorting

• Published in: PloS one 2023-01, Vol.18 (3), p.e0282810
• Main Authors: Eugen-Richard Ardelean, Andreea Coporîie, Ana-Maria Ichim, Mihaela Dînșoreanu, Raul Cristian Mureșan
• Format: Article
• Language: English
• ISSN: 1932-6203
• DOI: 10.1371/journal.pone.0282810

Spike sorting is the process of grouping spikes of distinct neurons into their respective clusters. Most frequently, this grouping is performed by relying on the similarity of features extracted from spike shapes. In spite of recent developments, current methods have yet to achieve satisfactory performance and many investigators favour sorting manually, even though it is an intensive undertaking that requires prolonged allotments of time. To automate the process, a diverse array of machine learning techniques has been applied. The performance of these techniques depends however critically on the feature extraction step. Here, we propose deep learning using autoencoders as a feature extraction method and evaluate extensively the performance of multiple designs. The models presented are evaluated on publicly available synthetic and real "in vivo" datasets, with various numbers of clusters. The proposed methods indicate a higher performance for the process of spike sorting when compared to other state-of-the-art techniques.