Efficacy and influential factors of hematoporphyrin monomethyl ether mediated photodynamic therapy in the treatment for port-wine stains

•Hematoporphyrin monomethyl ether mediated photodynamic therapy is effective for treating port-wine stain.•Lesion location and lesion sub-type influence efficacy.•Efficacy is correlated to the treatment times. Hematoporphyrin monomethyl ether mediated photodynamic therapy (HMME-PDT) has emerged as a...

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Published in:Photodiagnosis and photodynamic therapy 2024-02, Vol.45, p.103933-103933, Article 103933
Main Authors: Yu, Yanlan, Tang, Shichong, Luo, Youquan, Zheng, Mengxue, He, Wanzhen, Liu, Yueling, Xiao, Yan, Yin, Rui
Format: Article
Language:English
Subjects:
Adult
Hematoporphyrin monomethyl ether
Hematoporphyrins - therapeutic use
Humans
Photochemotherapy - methods
Photodynamic therapy
Photosensitizing Agents - therapeutic use
Port-wine stain
Port-Wine Stain - drug therapy
Treatment Outcome
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Summary:•Hematoporphyrin monomethyl ether mediated photodynamic therapy is effective for treating port-wine stain.•Lesion location and lesion sub-type influence efficacy.•Efficacy is correlated to the treatment times. Hematoporphyrin monomethyl ether mediated photodynamic therapy (HMME-PDT) has emerged as an alternative approach for port-wine stain (PWS), which was primarily treated with pulsed dye laser (PDL). This study was aimed to evaluate the efficacy and safety of HMME-PDT for PWS and to explore influential factors on the efficacy. A total of 254 patients were enrolled. Patients received an intravenous injection of HMME at 5 mg/kg. Lesion areas were irradiated with 532-nm light for 20–25 min. Efficacy was assessed according to fading of lesions and graded as excellent (≥90 %), good (60 %–89 %), fair (20 %–59 %), or poor (
ISSN:1572-1000
1873-1597
DOI:10.1016/j.pdpdt.2023.103933