Optically-excited simultaneous photoacoustic and ultrasound imaging based on a flexible gold-PDMS film

We constructed a flexible gold-polydimethylsiloxane (gold-PDMS) nanocomposites film with controllable thickness and light transmittance, to realize optically-excited simultaneous photoacoustic (PA) and ultrasound (US) imaging under a single laser pulse irradiation. Benefiting from the excellent ther...

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Bibliographic Details
Published in:Journal of innovative optical health science 2020-07, Vol.13 (4), p.2050012-1-2050012-10
Main Authors: Cui, Dandan, Zhang, Zhenhui, Shi, Yujiao
Format: Article
Language:English
Subjects:
finite element analysis (fea)
Finite element method
Frequency analysis
Gold
gold-polydimethylsiloxane (gold-pdms) nanocomposites film
Imaging
Irradiation
Light transmittance
Nanocomposites
photoacoustic and ultrasound imaging
Polydimethylsiloxane
Stability
Thermoelastic properties
Thickness
Ultrasonic imaging
Ultrasound
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Summary:We constructed a flexible gold-polydimethylsiloxane (gold-PDMS) nanocomposites film with controllable thickness and light transmittance, to realize optically-excited simultaneous photoacoustic (PA) and ultrasound (US) imaging under a single laser pulse irradiation. Benefiting from the excellent thermoelastic properties, the gold-PDMS film absorbs part of the incident laser energy and produces a high-intensity US, which is used to realize US imaging. Meanwhile, the partly transmitted light is used to excite samples for PA imaging. By controlling the thickness of the gold-PDMS, we can control the center frequency in the US imaging. We experimentally analyzed the frequency of the produced US signal by the gold-PDMS film and compared it with the finite element analysis (FEA) method, where the experiments agree with the FEA results. This method is demonstrated by the experiments on phantoms and a mouse model. Our work provides a cost-effective methodology for simultaneous PA and US imaging.
ISSN:1793-5458
1793-7205
DOI:10.1142/S1793545820500121