Spontaneous neural activity in the three principal networks underlying delay discounting: a resting-state fMRI study

• Published in: Frontiers in psychiatry 2024, Vol.15, p.1320830-1320830
• Main Authors: Ji, Songyue, Yang, Fan, Li, Xueting
• Format: Article
• Language: English
• Subjects: delay discounting; functional connectivity; ReHo; resting-state fMRI; the tripartite network model
• ISSN: 1664-0640; 1664-0640
• DOI: 10.3389/fpsyt.2024.1320830

Delay discounting, the decline in the subjective value of future rewards over time, has traditionally been understood through a tripartite neural network model, comprising the valuation, cognitive control, and prospection networks. To investigate the applicability of this model in a resting-state context, we employed a monetary choice questionnaire to quantify delay discounting and utilized resting-state functional magnetic resonance imaging (rs-fMRI) to explore the role of spontaneous brain activity, specifically regional homogeneity (ReHo), in influencing individual differences in delay discounting across a large cohort ( = 257). Preliminary analyses revealed a significant negative correlation between delay discounting tendencies and the ReHo in both the left insula and the right hippocampus, respectively. Subsequent resting-state functional connectivity (RSFC) analyses, using these regions as seed ROIs, disclosed that all implicated brain regions conform to the three principal networks traditionally associated with delay discounting. Our findings offer novel insights into the role of spontaneous neural activity in shaping individual variations in delay discounting at both regional and network levels, providing the first empirical evidence supporting the applicability of the tripartite network model in a resting-state context.