A Liquid Biopsy in Bladder Cancer—The Current Landscape in Urinary Biomarkers

The non-muscle invasive bladder cancer tends to recur and progress. Therefore, it requires frequent follow-ups, generating costs and making it one of the most expensive neoplasms. Considering the expensive and invasive character of the current gold-standard diagnostic procedure, white-light cystosco...

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Bibliographic Details
Published in:International journal of molecular sciences 2022-08, Vol.23 (15), p.8597
Main Authors: Matuszczak, Milena, Kiljańczyk, Adam, Salagierski, Maciej
Format: Article
Language:English
Subjects:
biological fluids
Biomarkers
Biopsy
Bladder cancer
Cancer
cancer biomarkers
cell-free DNA
Cellular biology
DNA methylation
Hematuria
Invasiveness
liquid biopsy
Medical prognosis
Muscles
Neoplasms
personalized therapy
precision oncology
Prognosis
Review
Tumors
Urine
Urogenital system
White light
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Description
Summary:The non-muscle invasive bladder cancer tends to recur and progress. Therefore, it requires frequent follow-ups, generating costs and making it one of the most expensive neoplasms. Considering the expensive and invasive character of the current gold-standard diagnostic procedure, white-light cystoscopy, efforts to find an alternative method are ongoing. Although the last decade has seen significant advancements in urinary biomarker tests (UBTs) for bladder cancer, international guidelines have not recommended them. Currently, the paramount urgency is to find and validate the test with the best specificity and sensitivity, which would allow for the optimizing of diagnosis, prognosis, and a treatment plan. This review aims to summarise the up-to-date state of knowledge relating to UBTs and new developments in the detection, prognosis, and surveillance of bladder cancer and their potential applications in clinical practice.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms23158597