Efficacy of Calcium Chloride Dihydrate Supplementation at ICSI on Patient Outcomes

Background: ICSI typically results in fertilisation rates of >65% however patients may still have low or no fertilisation despite the oocyte and sperm quality appearing normal. After entry of the sperm into the oocyte, a cascade of reactions facilitates calcium release and subsequent oocyte activ...

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Bibliographic Details
Published in:Fertility & reproduction 2022-09, Vol.4 (3n04), p.207-207
Main Authors: POPKISS, Sophie, HORTA, Fabrizzio, VOLLENHOVEN, Beverly, GREEN, Mark P., ZANDER-FOX, Deirdre
Format: Article
Language:English
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Summary:Background: ICSI typically results in fertilisation rates of >65% however patients may still have low or no fertilisation despite the oocyte and sperm quality appearing normal. After entry of the sperm into the oocyte, a cascade of reactions facilitates calcium release and subsequent oocyte activation. In cases of poor or failed fertilisation it is possible that this cascade fails and therefore different methods of artificial oocyte activation are used to try and induce calcium release. Aim: To determine if calcium chloride dihydrate supplementation in the PVP (5mM) at the time of ICSI (ICSI-Ca) improves fertilisation, utilisation and clinical pregnancy rates compared to ICSI alone, particularly in patients with a history of low fertilisation (
ISSN:2661-3182
2661-3174
DOI:10.1142/S2661318222741182