A case of extremely prolonged viral shedding: Could cell cultures be a diagnostic tool to drive COVID-19 patient discharge?

•Case presentation of a patient positive for SARS-CoV-2 after 71 days from symptom onset.•After acute infection, patients positive for SARS-CoV-2 may not be a source of COVID-19 infection.•Viral culture can help interpreting SARS-CoV-2 positivity, limiting unnecessary isolation. This study addressed...

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Bibliographic Details
Published in:International journal of infectious diseases 2021-03, Vol.104, p.631-633
Main Authors: Mileto, Davide, Foschi, Antonella, Mancon, Alessandro, Merli, Stefania, Staurenghi, Federica, Pezzati, Laura, Rizzo, Alberto, Conti, Federico, Romeri, Francesca, Bernacchia, Dario, Meroni, Rachele, Rizzardini, Giuliano, Gismondo, Maria Rita, Micheli, Valeria
Format: Article
Language:English
Subjects:
Aged, 80 and over
Case Report
Cell Culture Techniques
COVID-19
COVID-19 - virology
Humans
Male
Patient Discharge
Real-Time Polymerase Chain Reaction
RT-PCR
SARS-CoV-2
SARS-CoV-2 - isolation & purification
Serology
Time Factors
Viral culture
Virus Shedding
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Summary:•Case presentation of a patient positive for SARS-CoV-2 after 71 days from symptom onset.•After acute infection, patients positive for SARS-CoV-2 may not be a source of COVID-19 infection.•Viral culture can help interpreting SARS-CoV-2 positivity, limiting unnecessary isolation. This study addressed the case of a patient with prolonged COVID-19 viral shedding, reported by Real-Time PCR, until 71 days from symptom onset. However, viral culture received negative results after 30 days from symptom onset. Therefore, viral culture may be a worthwhile test for patients requiring discharge, in particular for those presenting prolonged viral shedding.
ISSN:1201-9712
1878-3511
DOI:10.1016/j.ijid.2020.11.161