Association of Small Intestinal Bacterial Overgrowth With Heart Failure and Its Prediction for Short-Term Outcomes

• Published in: Journal of the American Heart Association 2021-04, Vol.10 (7), p.e015292-e015292
• Main Authors: Song, Yu, Liu, Yuan, Qi, Baozhen, Cui, Xiaotong, Dong, Xinyue, Wang, Yanyan, Han, Xueting, Li, Fuhai, Shen, Dongli, Zhang, Xian, Hu, Kai, Chen, Shiyao, Zhou, Jingmin, Ge, Junbo
• Format: Article
• Language: English
• Subjects: gut microbiota; heart failure; Original Research; outcome; small intestinal bacterial overgrowth
• ISSN: 2047-9980; 2047-9980
• DOI: 10.1161/JAHA.119.015292

Background Small intestinal bacterial overgrowth (SIBO) is a common pathological condition of intestinal microbiota. The prevalence of SIBO and its prognostic value in patients with heart failure (HF) are unknown. Methods and Results A total of 287 patients tested for SIBO using lactulose hydrogen-methane breath test were evaluated. At least 1 of the following criteria fulfilled was SIBO positive: patients with fasting hydrogen level ≥20 parts per million (ppm) or a ≥20 ppm rise in hydrogen by 90 minutes were diagnosed with SIBO (H ) positive; and patients with methane levels ≥10 ppm at any test point were diagnosed with SIBO (CH ) positive. The association between SIBO and the composite of cardiovascular death and HF rehospitalization was investigated. In 287 consecutive patients with HF, 128 (45%) were positive for SIBO. Our result showed SIBO increased the risk of HF rehospitalization in patients with HF with reduced ejection fraction (