Fluctuations of antimüllerian hormone, ovarian follicular reserve, and antioxidant status throughout the estrous cycle in aged mares

Senility influences fertility in women and companion animals, especially horses. This study aimed to investigate the effect of aging in horses on the daily changes in the dominant follicle (DF) dynamics and hemodynamics, antimüllerian hormone (AMH), enzymes, antioxidants, and ovarian hormones during...

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Published in:Open veterinary journal (Tripoli, Libya) Libya), 2024-11, Vol.14 (11), p.3132-3143
Main Authors: Aboelmaaty, Amal Mahmoud, Elgharieb, Abdalla E A, El-Debaky, Hazem Ahmed, Alkhadrawy, Jamal M H, Abou-Ahmed, Mostafa M, Ghallab, Abdelraouf M
Format: Article
Language:English
Subjects:
aging
Aging - physiology
Animals
Anti-Mullerian Hormone - blood
antimullerian hormone
Antioxidants - metabolism
Estradiol - blood
Estrous Cycle - blood
Estrous Cycle - physiology
Female
Horses - blood
Horses - physiology
keywords: mares
luteal dynamics
Ovarian Follicle - physiology
ovarian hormones
Ovarian Reserve - physiology
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Summary:Senility influences fertility in women and companion animals, especially horses. This study aimed to investigate the effect of aging in horses on the daily changes in the dominant follicle (DF) dynamics and hemodynamics, antimüllerian hormone (AMH), enzymes, antioxidants, and ovarian hormones during the estrous cycle. Ovaries of old mares ( = 5, age >20 years) and young native mares ( = 6, age 0.05) to decrease the DF antrum diameter but significantly decreased ( < 0.05) its area, antrum area, and color area % in addition to the decrease ( < 0.01) in the uterine horn diameter and area, estradiol, total cholesterol, LDH, NO, aging increased ( < 0.05) CL area and the ovarian artery PI, and tended ( > 0.05) to increase the ovarian artery resistance index. Aging in mares did not disturb AMH, the ovarian macro-environmental dynamics, follicle growth, and recruiting but the disrupted blood flow mediators, enzymes, and antioxidant status may affect the intrafollicular mediators and influence the oocyte quality.
ISSN:2218-6050
2226-4485
2218-6050
DOI:10.5455/OVJ.2024.v14.i11.44