Associations between the Severity of the Post-Acute COVID-19 Syndrome and Echocardiographic Abnormalities in Previously Healthy Outpatients Following Infection with SARS-CoV-2

The COVID-19 pandemic affected over 130 million individuals during more than one year. Due to the overload of health-care services, a great number of people were treated as outpatients, many of them subsequently developing post-acute COVID-19 syndrome. Our study was conducted on 150 subjects without...

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Published in:Biology (Basel, Switzerland) Switzerland), 2021-05, Vol.10 (6), p.469
Main Authors: Tudoran, Cristina, Tudoran, Mariana, Pop, Gheorghe Nicusor, Giurgi-Oncu, Catalina, Cut, Talida Georgiana, Lazureanu, Voichita Elena, Oancea, Cristian, Parv, Florina, Ciocarlie, Tudor, Bende, Felix
Format: Article
Language:English
Subjects:
cardiovascular abnormalities
Cardiovascular diseases
Coronaviruses
COVID-19
Echocardiography
Electrocardiography
Epidemics
Heart
Hypertension
Infections
Laboratories
Lungs
Pain
Pandemics
Pathology
Patients
Pericarditis
post-acute COVID-19 syndrome
Quality of life
Questionnaires
Severe acute respiratory syndrome coronavirus 2
Statistical analysis
transthoracic echocardiography
Velocity
Ventricle
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Summary:The COVID-19 pandemic affected over 130 million individuals during more than one year. Due to the overload of health-care services, a great number of people were treated as outpatients, many of them subsequently developing post-acute COVID-19 syndrome. Our study was conducted on 150 subjects without a history of cardiovascular diseases, treated as outpatients for a mild/moderate form of COVID-19 4 to 12 weeks prior to study inclusion, and who were diagnosed with post-acute COVID-19 and attended a cardiology evaluation with transthoracic echocardiography (TTE) for persisting symptoms. We detected various cardiac abnormalities in 38 subjects (25.33%), including pulmonary hypertension (9.33%), impaired left ventricular performance (8.66%), diastolic dysfunction (14%) and/or evidence of pericarditis (10%). We highlighted statistically significant correlations between the intensity of symptoms and quality of life scores with the severity of initial pulmonary injury, the number of weeks since COVID-19 and with TTE parameters characterizing the systolic and diastolic performance and pulmonary hypertension (p < 0.001). (Post-acute COVID-19 is a complex syndrome characterized by various symptoms, the intensity of which seem to be related to the severity and the time elapsed since the acute infection, and with persisting cardiac abnormalities.
ISSN:2079-7737
2079-7737
DOI:10.3390/biology10060469