The Role of Platelets in Infective Endocarditis

Over the last decade, the incidence of infective endocarditis (IE) has increased, with a change in the frequency of causative bacteria. Early evidence has substantially demonstrated the crucial role of bacterial interaction with human platelets, with no clear mechanistic characterization in the path...

Full description

Saved in:
Bibliographic Details
Published in:International journal of molecular sciences 2023-04, Vol.24 (8), p.7540
Main Authors: Braï, Mustapha Abdeljalil, Hannachi, Nadji, El Gueddari, Nabila, Baudoin, Jean-Pierre, Dahmani, Abderrhamane, Lepidi, Hubert, Habib, Gilbert, Camoin-Jau, Laurence
Format: Article
Language:English
Subjects:
Bacteria
Bacteriology
Blood Platelets - pathology
Cardiology and cardiovascular system
Emerging diseases
Endocarditis
Endocarditis, Bacterial - epidemiology
Endocarditis, Bacterial - microbiology
Endocarditis, Bacterial - pathology
Enterococcus faecalis
Human health and pathology
Humans
Infectious diseases
Infective endocarditis
Life Sciences
Microbiology and Parasitology
Parasitology
platelets
Prospective Studies
Review
Staphylococcus aureus
Viridans streptococci
Virology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Over the last decade, the incidence of infective endocarditis (IE) has increased, with a change in the frequency of causative bacteria. Early evidence has substantially demonstrated the crucial role of bacterial interaction with human platelets, with no clear mechanistic characterization in the pathogenesis of IE. The pathogenesis of endocarditis is so complex and atypical that it is still unclear how and why certain bacterial species will induce the formation of vegetation. In this review, we will analyze the key role of platelets in the physiopathology of endocarditis and in the formation of vegetation, depending on the bacterial species. We provide a comprehensive outline of the involvement of platelets in the host immune response, investigate the latest developments in platelet therapy, and discuss prospective research avenues for solving the mechanistic enigma of bacteria-platelet interaction for preventive and curative medicine.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms24087540