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Ageing: from inflammation to cancer
Ageing is the major risk factor for cancer development. Hallmark of the ageing process is represented by inflammaging, which is a chronic and systemic low-grade inflammatory process. Inflammation is also a hallmark of cancer and is widely recognized to influence all cancer stages from cell transform...
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Published in: | Immunity & ageing 2018-01, Vol.15 (1), p.1-1, Article 1 |
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creator | Leonardi, Giulia C Accardi, Giulia Monastero, Roberto Nicoletti, Ferdinando Libra, Massimo |
description | Ageing is the major risk factor for cancer development. Hallmark of the ageing process is represented by inflammaging, which is a chronic and systemic low-grade inflammatory process. Inflammation is also a hallmark of cancer and is widely recognized to influence all cancer stages from cell transformation to metastasis. Therefore, inflammaging may represent the biological phenomena able to couple ageing process with cancer development. Here we review the molecular and cellular pathway involved in age-related chronic inflammation along with its potential triggers and their connection with cancer development. |
doi_str_mv | 10.1186/s12979-017-0112-5 |
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subjects | Ageing Aging Cancer DAMPs Genetic aspects Inflammation Metastasis Microbiota MiRna Physiological aspects Review Risk factors |
title | Ageing: from inflammation to cancer |
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