Inhibitory Effects of Constituents from the Aerial Parts of Rosmarinus officinalis L. on Triglyceride Accumulation

Sixteen flavonoids ( - ) including two new ones, named officinoflavonosides A ( ) and B ( ) were obtained from the aerial parts of . Among the known ones, , , and were isolated from the rosmarinus genus for the first time. Their structures were elucidated by chemical and spectroscopic methods. Moreo...

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Bibliographic Details
Published in:Molecules (Basel, Switzerland) Switzerland), 2017-01, Vol.22 (1), p.110-110
Main Authors: Li, Jian, Adelakun, Tiwalade Adegoke, Wang, Sijian, Ruan, Jingya, Yang, Shengcai, Li, Xiaoxia, Zhang, Yi, Wang, Tao
Format: Article
Language:English
Subjects:
Accumulation
Flavonoids
Flavonoids - chemistry
Hep G2 Cells
HepG2 cells
Humans
Lipid metabolism
Lipids
Molecular Structure
Oleic Acid - chemistry
phenolic acids
Phytochemicals - chemistry
Plant Components, Aerial - chemistry
Plant Extracts - chemistry
Rosmarinus - chemistry
Rosmarinus officinalis
Sodium oleate
Terpenes - chemistry
terpenoids
triglyceride accumulation inhibitory effects
Triglycerides
Triglycerides - metabolism
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Summary:Sixteen flavonoids ( - ) including two new ones, named officinoflavonosides A ( ) and B ( ) were obtained from the aerial parts of . Among the known ones, , , and were isolated from the rosmarinus genus for the first time. Their structures were elucidated by chemical and spectroscopic methods. Moreover, the effects on sodium oleate-induced triglyceride accumulation (TG) in HepG2 cells of the above-mentioned compounds and 16 other isolates ( - ) reported previously to have been obtained in the plant were analyzed. Results show that eight kinds of flavonoids (compounds , , , - and ) and seven kinds of other known isolates (compounds - , , and ) possessed significant inhibitory effects on intracellular TG content in HepG2 cells. Among them, the activities of compounds and were comparable to that of orlistat, which suggested that these compounds in this plant might be involved in lipid metabolism.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules22010110