A Study on the Reliability of an On-Site Oral Fluid Drug Test in a Recreational Context

The reliability of DrugWipe 5A on site test for principal drugs of abuse (cannabis, amphetamines, cocaine, and opiates) detection in oral fluid was assessed by comparing the on-site results with headspace solid-phase microextraction (HS-SPME) gas chromatography-mass spectrometry (GC-MS) analysis on...

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Bibliographic Details
Published in:Journal of analytical methods in chemistry 2016-01, Vol.2016 (2016), p.1-10
Main Authors: Mannocchi, Giulio, Tittarelli, Roberta, Solimini, Renata, Gentili, Stefano, Busardò, Francesco Paolo
Format: Article
Language:English
Subjects:
Amphetamines
Cannabis
Chromatography
Cocaine
Consumption
Devices
Drug testing
Drug use
Drugs
Ecstasy
Fluids
Gas chromatography
Laboratories
Mandatory drug testing
Marijuana
Mass spectrometry
Methamphetamine
Methods
Narcotics
NGOs
Nongovernmental organizations
Onsite
Risk management
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Summary:The reliability of DrugWipe 5A on site test for principal drugs of abuse (cannabis, amphetamines, cocaine, and opiates) detection in oral fluid was assessed by comparing the on-site results with headspace solid-phase microextraction (HS-SPME) gas chromatography-mass spectrometry (GC-MS) analysis on samples extracted by the device collection pad. Oral fluid samples were collected at recreational settings (e.g., discos, pubs, and music bars) of Rome metropolitan area. Eighty-three club goers underwent the on-site drug screening test with one device. Independently from the result obtained, a second device was used just to collect another oral fluid sample subsequently extracted and analyzed in the laboratory following HS-SPME procedure, gas chromatographic separation by a capillary column, and MS detection by electron impact ionization. DrugWipe 5A on-site test showed 54 samples (65.1%) positive to one or more drugs of abuse, whereas 75 samples (90.4%) tested positive for one or more substances following GC-MS assay. Comparing the obtained results, the device showed sensitivity, specificity, and accuracy around 80% for amphetamines class. Sensitivity (67 and 50%) was obtained for cocaine and opiates, while both sensitivity and accuracy were unsuccessful (29 and 53%, resp.) for cannabis, underlying the limitation of the device for this latter drug class.
ISSN:2090-8865
2090-8873
DOI:10.1155/2016/1234581