The relationship between chronic immune response and neurodegenerative damage in long COVID-19

• Published in: Frontiers in immunology 2022-12, Vol.13, p.1039427
• Main Authors: Elizalde-Díaz, José Pedro, Miranda-Narváez, Clara Leticia, Martínez-Lazcano, Juan Carlos, Martínez-Martínez, Eduardo
• Format: Article
• Language: English
• Subjects: autoantigens; autoantobodies; Chemokines; COVID-19; Humans; Immunity; Immunology; inflammatory response; Interferon-alpha; Interleukin-6; Ligands; long COVID syndrome; neurodegeneration; Neurodegenerative Diseases - etiology; Neurodegenerative Diseases - immunology; Neurodegenerative Diseases - physiopathology; Post-Acute COVID-19 Syndrome - complications; Post-Acute COVID-19 Syndrome - immunology; Post-Acute COVID-19 Syndrome - physiopathology; SARS-CoV-2
• ISSN: 1664-3224; 1664-3224
• DOI: 10.3389/fimmu.2022.1039427

In the past two years, the world has faced the pandemic caused by the severe acute respiratory syndrome 2 coronavirus (SARS-CoV-2), which by August of 2022 has infected around 619 million people and caused the death of 6.55 million individuals globally. Although SARS-CoV-2 mainly affects the respiratory tract level, there are several reports, indicating that other organs such as the heart, kidney, pancreas, and brain can also be damaged. A characteristic observed in blood serum samples of patients suffering COVID-19 disease in moderate and severe stages, is a significant increase in proinflammatory cytokines such as interferon-α (IFN-α), interleukin-1β (IL-1β), interleukin-2 (IL-2), interleukin-6 (IL-6) and interleukin-18 (IL-18), as well as the presence of autoantibodies against interferon-α (IFN-α), interferon-λ (IFN-λ), C-C motif chemokine ligand 26 (CCL26), CXC motif chemokine ligand 12 (CXCL12), family with sequence similarity 19 (chemokine (C-C motif)-like) member A4 (FAM19A4), and C-C motif chemokine ligand 1 (CCL1). Interestingly, it has been described that the chronic cytokinemia is related to alterations of blood-brain barrier (BBB) permeability and induction of neurotoxicity. Furthermore, the generation of autoantibodies affects processes such as neurogenesis, neuronal repair, chemotaxis and the optimal microglia function. These observations support the notion that COVID-19 patients who survived the disease present neurological sequelae and neuropsychiatric disorders. The goal of this review is to explore the relationship between inflammatory and humoral immune markers and the major neurological damage manifested in post-COVID-19 patients.