Genetic Profiling of the Plasmodium falciparum Population Using Antigenic Molecular Markers

About 50% of malaria infections in India are attributed to Plasmodium falciparum but relatively little is known about the genetic structure of the parasite populations. The molecular genotyping of the parasite populations by merozoite surface protein (msp1 and msp2) and glutamate-rich protein (glurp...

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Bibliographic Details
Published in:TheScientificWorld 2014, Vol.2014 (2014), p.1-7
Main Authors: Singh, Vineeta, Yadavendu, Veena, Raza, Adil, Khan, Haris M., Singh, Ruchi, Gupta, Purva, Bhatt, R. M.
Format: Article
Language:English
Subjects:
Drug resistance
Epitopes - genetics
Gene Expression Profiling - methods
Genes
Genetic aspects
Genetic diversity
Genetic Markers - genetics
Genetic screening
Genetic structure
Health aspects
Humans
India - epidemiology
Infections
Malaria
Malaria, Falciparum - diagnosis
Malaria, Falciparum - epidemiology
Malaria, Falciparum - genetics
Methods
Microscopy
Mutation
Parasites
Plasmodium falciparum
Plasmodium falciparum - genetics
Plasmodium falciparum - isolation & purification
Polymerase chain reaction
Polymorphism
Vector-borne diseases
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Summary:About 50% of malaria infections in India are attributed to Plasmodium falciparum but relatively little is known about the genetic structure of the parasite populations. The molecular genotyping of the parasite populations by merozoite surface protein (msp1 and msp2) and glutamate-rich protein (glurp) genes identifies the existing parasite population in the regions which help in understanding the molecular mechanisms involved in the parasite’s drive for survival. This study reveals the genetic profile of the parasite population in selected regions across the country with varying degree of endemicity among them. We also report the prevalence of Pfcrt mutations in this parasite population to evaluate the pattern of drug resistance development in them.
ISSN:2356-6140
1537-744X
1537-744X
DOI:10.1155/2014/140867