Genome-wide association study reveals HSF2, GJA1 and TRIM36 as susceptibility genes for preeclampsia: a community-based population study in Tianjin, China

• Published in: Hypertension in pregnancy 2023-12, Vol.42 (1), p.2256863-2256863
• Main Authors: Cao, Zhenhua, Ma, Li, Cai, Wei, Niu, Xiulong, Yang, Ning, Ni, Jianmei, Wang, Xiaojing, Wei, Maoti, Chen, Shaobo, Li, Yuming
• Format: Article
• Language: English
• Subjects: genome-wide association study (gwas); preeclampsia (pe); single-nucleotide polymorphisms (snps)
• ISSN: 1064-1955; 1525-6065
• DOI: 10.1080/10641955.2023.2256863

BACKGROUNDPreeclampsia (PE) mainly occurs in pregnant women and is hereditary. Several genome-wide association studies (GWAS) on Caucasian samples have reported some gene loci that are associated with preeclampsia. However, these studies have not reached consistent conclusions. No previous GWAS has examined preeclampsia in the Chinese Han population. METHODThis study aimed to identify common genetic variations associated with preeclampsia in the Chinese Han population through two-stage case‒control studies. The discovery cohort included 92 patients with severe preeclampsia and 187 healthy controls. The validation cohort included 52 patients with preeclampsia and 104 controls. A genome-wide association study was performed to identify putative preeclampsia genes in the discovery cohort, with validation in the validation cohort. RESULTSIn the discovery cohort, GWAS demonstrated that 19 single-nucleotide polymorphisms (SNPs) were associated with preeclampsia (P