Freezing response-independent facilitation of fear extinction memory in the prefrontal cortex

The infralimbic cortex (IL) is known to facilitate the formation of extinction memory through reciprocal interactions with the amygdala, which produces fear responses such as freezing. Thus, whether presynaptic input from the amygdala and post-synaptic output of IL neurons are functionally dissociat...

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Bibliographic Details
Published in:Scientific reports 2017-07, Vol.7 (1), p.5363-6, Article 5363
Main Authors: Hong, Jiso, Kim, Daesoo
Format: Article
Language:English
Subjects:
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631/378/1457/1945
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Amygdala
Animals
Cold-Shock Response
Conditioned stimulus
Conditioning, Classical
Extinction, Psychological
Fear
Fear conditioning
Humanities and Social Sciences
Lasers
Male
Memory
Mice, Inbred C57BL
multidisciplinary
Prefrontal cortex
Prefrontal Cortex - physiology
Science
Science (multidisciplinary)
Tonic immobility
Vectors (Biology)
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Summary:The infralimbic cortex (IL) is known to facilitate the formation of extinction memory through reciprocal interactions with the amygdala, which produces fear responses such as freezing. Thus, whether presynaptic input from the amygdala and post-synaptic output of IL neurons are functionally dissociated in extinction memory formation remains unclear. Here, we demonstrated that photostimulation of IL inputs from BLA did not change freezing responses to conditioned stimuli (CS) during training, but did facilitate extinction memory, measured as a reduction in freezing responses to the CS 1 day later. On the other hand, photostimulation of somata of IL neurons induced an immediate reduction in freezing to CS, but this did not affect extinction memory tested the next day. These results provide in vivo evidence for IL-dependent facilitation of extinction memory without post-synaptic modulation of freezing circuits.
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-017-04335-y