Antimicrobial Activity Enhancers: Towards Smart Delivery of Antimicrobial Agents

The development of effective treatments against infectious diseases is an extensive and ongoing process due to the rapid adaptation of bacteria to antibiotic-based therapies. However, appropriately designed activity enhancers, including antibiotic delivery systems, can increase the effectiveness of...

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Bibliographic Details
Published in:Antibiotics (Basel) 2022-03, Vol.11 (3), p.412
Main Authors: Skwarczynski, Mariusz, Bashiri, Sahra, Yuan, Ye, Ziora, Zyta M, Nabil, Osama, Masuda, Keita, Khongkow, Mattaka, Rimsueb, Natchanon, Cabral, Horacio, Ruktanonchai, Uracha, Blaskovich, Mark A T, Toth, Istvan
Format: Article
Language:English
Subjects:
activity enhancers
antibiotic
Antibiotics
Antimicrobial activity
Antimicrobial agents
Antimicrobial resistance
Bacteria
Bacterial infections
Biofilms
delivery systems
Drug delivery
Drug delivery systems
Drug dosages
E coli
Fatalities
Gene expression
Gram-negative bacteria
Gram-positive bacteria
Infectious diseases
Ligands
Lipids
Membranes
Metabolism
Microorganisms
Molecular weight
Multidrug resistance
Nanoparticles
Oxidative stress
Pathogens
Peptides
Permeability
Pharmaceutical industry
Polymers
Proteins
Review
Side effects
silver
Streptococcus infections
System effectiveness
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Summary:The development of effective treatments against infectious diseases is an extensive and ongoing process due to the rapid adaptation of bacteria to antibiotic-based therapies. However, appropriately designed activity enhancers, including antibiotic delivery systems, can increase the effectiveness of current antibiotics, overcoming antimicrobial resistance and decreasing the chance of contributing to further bacterial resistance. The activity/delivery enhancers improve drug absorption, allow targeted antibiotic delivery, improve their tissue and biofilm penetration and reduce side effects. This review provides insights into various antibiotic activity enhancers, including polymer, lipid, and silver-based systems, designed to reduce the adverse effects of antibiotics and improve formulation stability and efficacy against multidrug-resistant bacteria.
ISSN:2079-6382
2079-6382
DOI:10.3390/antibiotics11030412