Clostridioides difficile Infection in Patients with Inflammatory Bowel Disease May be Favoured by the Effects of Proinflammatory Cytokines on the Enteroglial Network

infection is widespread throughout countries and represents an important cause of nosocomial diarrhoea, with relatively high morbidity. This infection often occurs in patients with inflammatory bowel diseases and may complicate their clinical picture. Here, we propose, on the basis of evidence from...

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Bibliographic Details
Published in:Journal of inflammation research 2021-01, Vol.14, p.7443-7453
Main Authors: Bassotti, Gabrio, Fruganti, Alessandro, Maconi, Giovanni, Marconi, Pierfrancesco, Fettucciari, Katia
Format: Article
Language:English
Subjects:
Abdomen
Abscesses
Antibiotics
Apoptosis
Biological response modifiers
Cell cycle
Chemokines
Clostridioides difficile
clostridioides difficile infection
Cytokines
Cytotoxicity
Diarrhea
Gastrointestinal diseases
Glial cells
Health aspects
Hospitals
Immune system
Infection
Infections
Inflammation
Inflammatory bowel disease
Inflammatory bowel diseases
Interferon
Interferon gamma
Intestine
Medical research
Medicine, Experimental
Morbidity
Mortality
Patients
Senescence
Toxin B
Tumor necrosis factor
Tumor necrosis factor-TNF
Tumors
tumour necrosis factor alpha
Virulence
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Summary:infection is widespread throughout countries and represents an important cause of nosocomial diarrhoea, with relatively high morbidity. This infection often occurs in patients with inflammatory bowel diseases and may complicate their clinical picture. Here, we propose, on the basis of evidence from basic science studies, that in patients affected by inflammatory bowel diseases, this infection might be facilitated by a derangement of the enteric glial cell (EGC) network caused by the effects of proinflammatory cytokines, such as tumour necrosis factor alpha and interferon gamma, which enhance the cytotoxic effects of toxin B on EGCs. This hypothesis, if confirmed, could open the door to alternative treatment approaches to fight infection.
ISSN:1178-7031
1178-7031
DOI:10.2147/JIR.S328628