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Clostridioides difficile Infection in Patients with Inflammatory Bowel Disease May be Favoured by the Effects of Proinflammatory Cytokines on the Enteroglial Network
infection is widespread throughout countries and represents an important cause of nosocomial diarrhoea, with relatively high morbidity. This infection often occurs in patients with inflammatory bowel diseases and may complicate their clinical picture. Here, we propose, on the basis of evidence from...
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| Published in: | Journal of inflammation research 2021-01, Vol.14, p.7443-7453 |
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| container_title | Journal of inflammation research |
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| creator | Bassotti, Gabrio Fruganti, Alessandro Maconi, Giovanni Marconi, Pierfrancesco Fettucciari, Katia |
| description | infection is widespread throughout countries and represents an important cause of nosocomial diarrhoea, with relatively high morbidity. This infection often occurs in patients with inflammatory bowel diseases and may complicate their clinical picture. Here, we propose, on the basis of evidence from basic science studies, that in patients affected by inflammatory bowel diseases, this infection might be facilitated by a derangement of the enteric glial cell (EGC) network caused by the effects of proinflammatory cytokines, such as tumour necrosis factor alpha and interferon gamma, which enhance the cytotoxic effects of
toxin B on EGCs. This hypothesis, if confirmed, could open the door to alternative treatment approaches to fight
infection. |
| doi_str_mv | 10.2147/JIR.S328628 |
| format | article |
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toxin B on EGCs. This hypothesis, if confirmed, could open the door to alternative treatment approaches to fight
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This infection often occurs in patients with inflammatory bowel diseases and may complicate their clinical picture. Here, we propose, on the basis of evidence from basic science studies, that in patients affected by inflammatory bowel diseases, this infection might be facilitated by a derangement of the enteric glial cell (EGC) network caused by the effects of proinflammatory cytokines, such as tumour necrosis factor alpha and interferon gamma, which enhance the cytotoxic effects of
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infection.</abstract><cop>New Zealand</cop><pub>Dove Medical Press Limited</pub><pmid>35002278</pmid><doi>10.2147/JIR.S328628</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0002-2256-6174</orcidid><orcidid>https://orcid.org/0000-0002-0237-1812</orcidid><orcidid>https://orcid.org/0000-0003-0810-4026</orcidid><orcidid>https://orcid.org/0000-0001-8074-8243</orcidid><oa>free_for_read</oa></addata></record> |
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| source | Taylor & Francis Open Access; Publicly Available Content Database; PubMed; Coronavirus Research Database |
| subjects | Abdomen Abscesses Antibiotics Apoptosis Biological response modifiers Cell cycle Chemokines Clostridioides difficile clostridioides difficile infection Cytokines Cytotoxicity Diarrhea Gastrointestinal diseases Glial cells Health aspects Hospitals Immune system Infection Infections Inflammation Inflammatory bowel disease Inflammatory bowel diseases Interferon Interferon gamma Intestine Medical research Medicine, Experimental Morbidity Mortality Patients Senescence Toxin B Tumor necrosis factor Tumor necrosis factor-TNF Tumors tumour necrosis factor alpha Virulence |
| title | Clostridioides difficile Infection in Patients with Inflammatory Bowel Disease May be Favoured by the Effects of Proinflammatory Cytokines on the Enteroglial Network |
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