The Interplay between Toxic and Essential Metals for Their Uptake and Translocation Is Likely Governed by DNA Methylation and Histone Deacetylation in Maize

The persistent nature of lead (Pb) and cadmium (Cd) in the environment severely affects plant growth and yield. Conversely, plants acquire zinc (Zn) from the soil for their vital physiological and biochemical functions. However, the interplay and coordination between essential and toxic metals for t...

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Bibliographic Details
Published in:International journal of molecular sciences 2020-09, Vol.21 (18), p.6959
Main Authors: Shafiq, Sarfraz, Ali, Asim, Sajjad, Yasar, Zeb, Qudsia, Shahzad, Muhammad, Khan, Abdul Rehman, Nazir, Rashid, Widemann, Emilie
Format: Article
Language:English
Subjects:
Biological Transport
DNA Methylation
DNA, Plant - metabolism
heavy metals interplay
histone deacetylases
Histone Deacetylases - metabolism
Histones - metabolism
maize
Metals - metabolism
phytotoxcity
Plant Proteins - metabolism
Plant Roots - metabolism
Zea mays - metabolism
Zn transporters (ZIP)
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Summary:The persistent nature of lead (Pb) and cadmium (Cd) in the environment severely affects plant growth and yield. Conversely, plants acquire zinc (Zn) from the soil for their vital physiological and biochemical functions. However, the interplay and coordination between essential and toxic metals for their uptake and translocation and the putative underlying epigenetic mechanisms have not yet been investigated in maize. Here, we report that the presence of Zn facilitates the accumulation and transport of Pb and Cd in the aerial parts of the maize plants. Moreover, the Zn, Pb, and Cd interplay specifically interferes with the uptake and translocation of other divalent metals, such as calcium and magnesium. Zn, Pb, and Cd, individually and in combinations, differentially regulate the expression of DNA methyltransferases, thus alter the DNA methylation levels at the promoter of ( ) genes to regulate their expression. Furthermore, the expression of histone deacetylases ( ) varies greatly in response to individual and combined metals, and expression showed a negative correlation with transporters. Our study highlights the implication of DNA methylation and histone acetylation in regulating the metal stress tolerance dynamics through Zn transporters and warns against the excessive use of Zn fertilizers in metal contaminated soils.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms21186959