Poly[3-(3,4-dihydroxyphenyl)glyceric Acid], A New Biologically Active Polymer from Symphytum Asperum Lepech. and S.Caucasicum Bieb. (Boraginaceae)

Two high-molecular water-soluble preparations with high anticomplementary, antioxidant, antilipoperoxidant and antiinflammatory activities were isolated from the roots of Symphytum asperum and S. caucasicum. Their main chemical constituent was found to be poly[oxy-1-carboxy-2-(3,4-dihydroxyphenyl)et...

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Bibliographic Details
Published in:Molecules (Basel, Switzerland) Switzerland), 2005-09, Vol.10 (9), p.1135-1144
Main Authors: Barbakadze, V., Kemertelidze, E., Targamadze, I., Mulkijanyan, K., Shashkov, A., Usov, A.
Format: Article
Language:English
Subjects:
4-dihydroxyphenyl)ethylene
4-dihydroxyphenyl)glyceric acid
Acids
Caffeic acid
Carbon
Cell cycle
Lignin
poly[oxy-1-carboxy-2-
Polymers
Symphytum asperum
Symphytum asperum caucasicum
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Summary:Two high-molecular water-soluble preparations with high anticomplementary, antioxidant, antilipoperoxidant and antiinflammatory activities were isolated from the roots of Symphytum asperum and S. caucasicum. Their main chemical constituent was found to be poly[oxy-1-carboxy-2-(3,4-dihydroxyphenyl)ethylene], according to IR and NMR spectroscopy. The Symphytum high-molecular preparations can modulate in vitro B- chronic lymphocytic leukaemia (B-CLL) cells apoptosis and cell cycle progression.
ISSN:1420-3049
1420-3049
DOI:10.3390/10091135