Therapeutic Effect of Lactiplantibacillus plantarun HFY11 Isolated from Naturally Fermented Yak Yogurt on Lincomycin Hydrochloride-Induced Diarrhea in Mice

This study aimed to observe the therapeutic effect of HFY11 (LP-HFY11) on lincomycin hydrochloride-induced diarrhea in mice. The results showed that LP-HFY11 alleviated weight loss and intestinal and colon tissue lesions caused by diarrhea. The serum assay showed that LP-HFY11 decreased interleukin...

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Bibliographic Details
Published in:Microorganisms (Basel) 2024-11, Vol.12 (11), p.2307
Main Authors: Tan, Fang, Ren, Lixuan, Kong, Chang-Suk
Format: Article
Language:English
Subjects:
Acids
Animal tissues
Antibacterial agents
Antibiotics
Bacteria
Bacterial infections
Bifidobacterium
Bile
Colon
Cystic fibrosis
Diarrhea
Down-regulation
Epidermal growth factor
Epidermal growth factor receptors
expression
Fermentation
Gene expression
Growth factors
Health aspects
Inflammatory diseases
Interleukins
Lactiplantibacillus
Lactiplantibacillus plantarun
Life sciences
Lincomycin
lincomycin hydrochloride
mice
Microorganisms
Na+/H+-exchanging ATPase
Physiology
Polymerase chain reaction
Probiotics
RNA
Salt
Small intestine
Transforming growth factor-b1
Transforming growth factors
Weight loss
Yogurt
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Summary:This study aimed to observe the therapeutic effect of HFY11 (LP-HFY11) on lincomycin hydrochloride-induced diarrhea in mice. The results showed that LP-HFY11 alleviated weight loss and intestinal and colon tissue lesions caused by diarrhea. The serum assay showed that LP-HFY11 decreased interleukin 17A (IL-17A), IL-6, 5-hydroxytryptamine, and malondialdehyde levels and increased total antioxidant capacity in mice with diarrhea. LP-HFY11 also downregulated the mRNA expression of cystic fibrosis transmembrane conductance regulator (CFTR), epidermal growth factor receptor (EGFR), and transforming growth factor beta 1 (TGFβ1) and upregulated the expression of recombinant sodium/hydrogen exchanger 1 (NHE1) and NHE4 in the colon tissues of mice with diarrhea. In conclusion, the study showed that LP-HFY11 could effectively inhibit diarrhea, and the effect was better than that of the drug tetragenous viable bacteria tablets ( -TVBT).
ISSN:2076-2607
2076-2607
DOI:10.3390/microorganisms12112307