Novel Oncogenic Value of C10orf90 in Colon Cancer Identified as a Clinical Diagnostic and Prognostic Marker

C10orf90, a tumor suppressor, can inhibit the occurrence and development of tumors. Therefore, we investigated the gene function of in various tumors using multiple pan-cancer datasets. Pan-cancer analysis results reveal that the expression levels of vary across different tumors and hold significant...

Full description

Saved in:
Bibliographic Details
Published in:International journal of molecular sciences 2024-10, Vol.25 (19), p.10496
Main Authors: Ruan, Chuangdong, Zhang, Yuqin, Chen, Daoyang, Zhu, Mengyi, Yang, Penghui, Zhang, Rongxin, Li, Yan
Format: Article
Language:English
Subjects:
Apoptosis
Apoptosis - genetics
Biomarkers, Tumor - genetics
Breast cancer
C10orf90
Cell Line, Tumor
Cell Movement - genetics
Cell Proliferation - genetics
Chromosomes
COAD
Colon
Colon cancer
Colonic Neoplasms - diagnosis
Colonic Neoplasms - genetics
Colonic Neoplasms - pathology
comprehensive analysis
Development and progression
Diagnosis
DNA damage
DNA Methylation
Gene Expression Regulation, Neoplastic
Genetic aspects
Humans
Localization
Medical prognosis
Melanoma
pan-cancer
Physiological aspects
Prognosis
Protein expression
Proteins
Tumor suppressor genes
Tumors
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:C10orf90, a tumor suppressor, can inhibit the occurrence and development of tumors. Therefore, we investigated the gene function of in various tumors using multiple pan-cancer datasets. Pan-cancer analysis results reveal that the expression levels of vary across different tumors and hold significant value in the clinical diagnosis and prognosis of patients with various tumors. In some cancers, the expression level of is correlated with CNV, DNA methylation, immune subtypes, immune cell infiltration, and drug sensitivity in the tumors. In particular, in COAD, the gene is implicated in multiple processes associated with COAD. Cell experiments demonstrate that suppresses the proliferation and migration of colon cancer cells while promoting apoptosis. In summary, plays a role in the onset and progression of various cancers and could potentially serve as an effective diagnostic and prognostic marker for cancer patients. Notably, in COAD, inhibits the proliferation and migration of colon cancer cells, induces apoptosis, and is linked to the advancement of colon cancer.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms251910496