Dosimetric Comparison of Helical Tomotherapy and Intensity-Modulated Proton Therapy in Hippocampus- and Scalp-Sparing Whole Brain Radiotherapy

Objective: Cognitive decline and alopecia after radiotherapy are challenging problems. We aimed to compare whole brain radiotherapy (WBRT) plans reducing radiation dose to the hippocampus and scalp between helical tomotherapy (HT) and intensity-modulated proton therapy (IMPT). Methods: We conducted...

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Bibliographic Details
Published in:Technology in cancer research & treatment 2021, Vol.20, p.15330338211060170-15330338211060170
Main Authors: Takaoka, Taiki, Tomita, Natsuo, Mizuno, Tomoki, Hashimoto, Shingo, Tsuchiya, Takahiro, Tomida, Masashi, Yanagi, Takeshi
Format: Article
Language:English
Subjects:
Alopecia
Baldness
Cognitive ability
Conformity
Cranial Irradiation - adverse effects
Cranial Irradiation - methods
Cranial Irradiation - standards
Hippocampus
Hippocampus - diagnostic imaging
Hippocampus - radiation effects
Humans
Magnetic Resonance Imaging
Organs at Risk
Original
Proton Therapy - adverse effects
Proton Therapy - methods
Proton Therapy - standards
Radiation therapy
Radiometry
Radiotherapy Dosage
Radiotherapy Planning, Computer-Assisted
Radiotherapy, Image-Guided - adverse effects
Radiotherapy, Image-Guided - methods
Radiotherapy, Image-Guided - standards
Radiotherapy, Intensity-Modulated - adverse effects
Radiotherapy, Intensity-Modulated - methods
Radiotherapy, Intensity-Modulated - standards
Scalp
Tomography, Spiral Computed
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Summary:Objective: Cognitive decline and alopecia after radiotherapy are challenging problems. We aimed to compare whole brain radiotherapy (WBRT) plans reducing radiation dose to the hippocampus and scalp between helical tomotherapy (HT) and intensity-modulated proton therapy (IMPT). Methods: We conducted a planning study of WBRT for 10 patients. The clinical target volume was defined as the whole brain excluding the hippocampus avoidance (HA) region. The prescribed dose was 30 Gy in 10 fractions to cover 95% of the target. Constraint goals were defined for the target and organs at risk (OAR). Results: Both techniques met the dose constraints for the target and OAR. However, the coverage of the target (dose covering 95% [D95%] and 98% [D98%] of the volume) were better in IMPT than HT (HT vs IMPT: D95%, 29.9 Gy vs 30.0 Gy, P 
ISSN:1533-0346
1533-0338
DOI:10.1177/15330338211060170