Advanced Biomarkers of Hepatotoxicity in Psychiatry: A Narrative Review and Recommendations for New Psychoactive Substances

One of the factors that increase the effectiveness of the pharmacotherapy used in patients abusing various types of new psychoactive substances (NPSs) is the proper functioning of the liver. However, the articles published to date on NPS hepatotoxicity only address non-specific hepatic parameters. T...

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Bibliographic Details
Published in:International journal of molecular sciences 2023-05, Vol.24 (11), p.9413
Main Authors: Golub, Aniela, Ordak, Michal, Nasierowski, Tadeusz, Bujalska-Zadrozny, Magdalena
Format: Article
Language:English
Subjects:
Biomarkers
Chromosomal proteins
Drug therapy
Enzymes
Fibroblasts
Health aspects
Health care
Hepatitis C
Hepatitis C virus
Hepatotoxicity
HMGB1 protein
Infections
Inflammation
Kinases
Liver
Liver cancer
Liver diseases
Medical prognosis
Medical research
Medicine, Experimental
Mental disorders
new psychoactive substances
Osteopontin
Pathogenesis
Proteins
Psychiatry
Psychotropic drugs
Review
Stem cells
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Summary:One of the factors that increase the effectiveness of the pharmacotherapy used in patients abusing various types of new psychoactive substances (NPSs) is the proper functioning of the liver. However, the articles published to date on NPS hepatotoxicity only address non-specific hepatic parameters. The aim of this manuscript was to review three advanced markers of hepatotoxicity in psychiatry, namely, osteopontin (OPN), high-mobility group box 1 protein (HMGB1) and glutathione dehydrogenase (GDH, GLDH), and, on this basis, to identify recommendations that should be included in future studies in patients abusing NPSs. This will make it possible to determine whether NPSs do indeed have a hepatotoxic effect or whether other factors, such as additional substances taken or hepatitis C virus (HCV) infection, are responsible. NPS abusers are at particular risk of HCV infection, and for this reason, it is all the more important to determine what factors actually show a hepatotoxic effect in them.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms24119413