Melanoma Prognosis and Associated Risk Factors: A Retrospective Cohort Study Using Semantic Map Analysis

The overall patterns of correlations among various melanoma risk factors have not yet been examined. The aim of this study was to assess the impact of different parameters on disease-free and melanoma-related overall survival. A retrospective cohort study was conducted encompassing all patients with...

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Bibliographic Details
Published in:Acta dermato-venereologica 2023-05, Vol.103, p.adv9591-adv9591
Main Authors: Cazzaniga, Simone, Zahn, Carole Anouk, Seyed Jafari, Seyed Morteza, Hunger, Robert Emil
Format: Article
Language:English
Subjects:
Humans
Lymph Nodes - pathology
melanoma
Melanoma - pathology
Melanoma, Cutaneous Malignant
Original Report
outcome
Prognosis
Retrospective Studies
risk factors
semantic map analysis
Semantics
Sentinel Lymph Node Biopsy
Skin Neoplasms - pathology
survival
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Summary:The overall patterns of correlations among various melanoma risk factors have not yet been examined. The aim of this study was to assess the impact of different parameters on disease-free and melanoma-related overall survival. A retrospective cohort study was conducted encompassing all patients with a primary cutaneous melanoma diagnosed in a university referral centre. Associations were explored using semantic map analysis, which uses graph theory to find the strongest path of connections between variables. A total of 1,110 melanoma patients (median follow-up 10.6 years) were included. The analysis revealed a clustering of variables around 2 main hubs: Breslow thickness  10 mm. This semantic analysis confirmed the close link between Breslow thickness, age, sentinel lymph node biopsy findings, skin type, melanoma subtype and prognosis, and provides prognostic information useful for the further stratification and management of patients with melanoma.
ISSN:0001-5555
1651-2057
DOI:10.2340/actadv.v103.9591