Localization of fat depots and cardiovascular risk

Despite the existing preventative and therapeutic measures, cardiovascular diseases remain the main cause of temporary disability, long-term disability, and mortality. Obesity is a major risk factor for cardiovascular diseases and their complications. However, not all fat depots have the same inflam...

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Bibliographic Details
Published in:Lipids in health and disease 2018-09, Vol.17 (1), p.218-218, Article 218
Main Authors: Gruzdeva, Olga, Borodkina, Daria, Uchasova, Evgenya, Dyleva, Yulia, Barbarash, Olga
Format: Article
Language:English
Subjects:
Abdomen
Adipocytes
Adipose tissue
Adipose Tissue - physiopathology
Atherosclerosis
Body fat
Body mass index
Cardiovascular disease
Cardiovascular diseases
Cardiovascular Diseases - epidemiology
Cardiovascular Diseases - physiopathology
Coronary vessels
Cytokines
Diabetes
Epicardial adipose tissue
Epidemiology
Health aspects
Health risk assessment
Heart
Humans
Hypertension
Inflammation
Insulin resistance
Intra-Abdominal Fat - physiopathology
Liver
Localization
Medical imaging
Metabolic syndrome
Mortality
NMR
Non-alcoholic fatty liver disease
Nuclear magnetic resonance
Obesity
Obesity - epidemiology
Obesity - metabolism
Obesity - physiopathology
Paracrine signalling
Perivascular adipose tissue
Prevention
Proteins
Review
Risk Factors
Subcutaneous Fat - physiopathology
Triglycerides
Tumor necrosis factor-TNF
Ultrasonic imaging
Visceral obesity
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Description
Summary:Despite the existing preventative and therapeutic measures, cardiovascular diseases remain the main cause of temporary disability, long-term disability, and mortality. Obesity is a major risk factor for cardiovascular diseases and their complications. However, not all fat depots have the same inflammatory, paracrine, and metabolic activities. In addition, recent studies have indicated that the accumulation of visceral fat, rather than subcutaneous fat, is associated with increased cardiometabolic risk. However, there is also evidence that increasing the area of visceral fat can help protect against lipotoxicity. This review aims to discuss the contemporary literature regarding the characteristics of the visceral, epicardial, and perivascular fat depots, as well as their associations with cardiovascular disease.
ISSN:1476-511X
1476-511X
DOI:10.1186/s12944-018-0856-8