The Roles of Lpar1 in Central Nervous System Disorders and Diseases

Lysophosphatidic acid receptor 1 (Lpar1) , which is found in almost all human tissues but is most abundant in the brain, can couple to G protein-coupled receptors (GPCRs) and participate in regulating cell proliferation, migration, survival, and apoptosis. Endothelial differentiation gene-2 receptor...

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Bibliographic Details
Published in:Frontiers in neuroscience 2021-07, Vol.15, p.710473-710473
Main Authors: Xiao, Dongqiong, Su, Xiaojuan, Gao, Hu, Li, Xihong, Qu, Yi
Format: Article
Language:English
Subjects:
Apoptosis
astrocyte
Astrocytes
astroglia
Binding sites
Biosynthesis
Brain
Cell cycle
Cell migration
Cell proliferation
Cell survival
Central nervous system
Demyelination
Edg2
Endoplasmic reticulum
G protein-coupled receptors
Kinases
Ligands
Lpar1
Lysophosphatidic acid
Mental disorders
Microglia
Morphology
Mutation
Nervous system
Neural stem cells
Neuralgia
Neurodevelopmental disorders
Neurogenesis
Neuroscience
oligodendrocyte
Oligodendrocytes
Proteins
Roles
Stem cells
Therapeutic targets
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Summary:Lysophosphatidic acid receptor 1 (Lpar1) , which is found in almost all human tissues but is most abundant in the brain, can couple to G protein-coupled receptors (GPCRs) and participate in regulating cell proliferation, migration, survival, and apoptosis. Endothelial differentiation gene-2 receptor (Edg2), the protein encoded by the Lpar1 gene, is present on various cell types in the central nervous system (CNS), such as neural stem cells (NSCs), oligodendrocytes, neurons, astrocytes, and microglia. Lpar1 deletion causes neurodevelopmental disorders and CNS diseases, such as brain cancer, neuropsychiatric disorders, demyelination diseases, and neuropathic pain. Here, we summarize the possible roles and mechanisms of Lpar1/ Edg2 in CNS disorders and diseases and propose that Lpar1/ Edg2 might be a potential therapeutic target for CNS disorders and diseases.
ISSN:1662-453X
1662-4548
1662-453X
DOI:10.3389/fnins.2021.710473