Editorial: The known, the unknown, and the future of glutamate transporters

[...]maintenance of the glutamate extracellular concentration involves tight control of its release and uptake. [...]the cystine/glutamate exchanger, also known as system x−c xc− , exports glutamate in exchange for cystine (Jabaudon et al., 1999; Warr et al., 1999; Featherstone and Shippy, 2008). Ab...

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Published in:Frontiers in cellular neuroscience 2022-08, Vol.16, p.1005834-1005834
Main Authors: Martinez-Lozada, Zila, Hewett, Sandra J., Zafra, Francisco, Ortega, Arturo
Format: Article
Language:English
Subjects:
Alzheimer's disease
Blood flow
Brain research
Cellular Neuroscience
Conflicts of interest
excitatory amino acid transporter (EAAT)
Excitatory amino acid transporter 2
Fibroblasts
glutamate
glutamate transport
Homeostasis
Nervous system
Overexpression
Physiology
Proteins
system xc
vesicular glutamate transport proteins
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creator Martinez-Lozada, Zila
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description [...]maintenance of the glutamate extracellular concentration involves tight control of its release and uptake. [...]the cystine/glutamate exchanger, also known as system x−c xc− , exports glutamate in exchange for cystine (Jabaudon et al., 1999; Warr et al., 1999; Featherstone and Shippy, 2008). Abnormalities in uptake and motor function were alleviated via over-expression of a C-terminal truncated EAAT2 protein (Hirschberg et al.). Because most of the glutamate clearance (80–90%) is mediated by astrocytic EAAT2/GLT-1, the function of GLT-1 in other cell types has remained largely unexplored. [...]the Robinson group used pharmacological inhibition of EAAT function to demonstrate their importance to arteriole patency (Jackson et al.), highlighting another important function of EAATs, which is to act as a bridge between local neuronal activity and increases in blood flow.
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subjects Alzheimer's disease
Blood flow
Brain research
Cellular Neuroscience
Conflicts of interest
excitatory amino acid transporter (EAAT)
Excitatory amino acid transporter 2
Fibroblasts
glutamate
glutamate transport
Homeostasis
Nervous system
Overexpression
Physiology
Proteins
system xc
vesicular glutamate transport proteins
title Editorial: The known, the unknown, and the future of glutamate transporters
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