Predicting the prognosis of Wilms tumor by peripheral blood cells: a real-world study of more than 30 years

Despite established excellent treatment strategies for Wilms tumor (WT), effective prognostic evaluation methods were lacking. This study aims to examine prognostic factors for WT through real-world peripheral blood cell profiling. Basic data and pre-treatment laboratory indices from WT and non-WT c...

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Bibliographic Details
Published in:Italian journal of pediatrics 2024-11, Vol.50 (1), p.245-11, Article 245
Main Authors: Jie, Lin, Qin-Lin, Shi, Xiao-Mao, Tian, Peng, Hong, Zhuang-Cheng, Wang, Zai-Hong, Hu, Kong-Kong, Cui, Zhi-Qiang, Gao, Feng, Liu, Tao, Lin, Guang-Hui, Wei
Format: Article
Language:English
Subjects:
Blood cells
Child
Child, Preschool
Female
Humans
Infant
Kidney Neoplasms - blood
Kidney Neoplasms - mortality
Kidney Neoplasms - therapy
Male
Neoplasm Staging
Nomograms
Overall survival
Prognosis
Retrospective Studies
Risk stratification
Survival Rate
Wilms tumor
Wilms Tumor - blood
Wilms Tumor - mortality
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Summary:Despite established excellent treatment strategies for Wilms tumor (WT), effective prognostic evaluation methods were lacking. This study aims to examine prognostic factors for WT through real-world peripheral blood cell profiling. Basic data and pre-treatment laboratory indices from WT and non-WT children underwent Wilcoxon test analysis. Chi-square tests assessed the correlation between blood cells and the overall survival (OS) and event-free survival (EFS) of WT. Further the Log-rank test and multivariate Cox were used to identify independent prognostic factors for OS. Traditional accepted factors were included in multi-Cox and the nomogram was constructed to further validate the outcome. Blood cells significantly differed between WT and non-WT groups (P 
ISSN:1824-7288
1824-7288
DOI:10.1186/s13052-024-01805-8