Gut Microbiota and Type 1 Diabetes

Recently, the onset of type 1 diabetes (T1D) has increased rapidly and became a major public health concern worldwide. Various factors are associated with the development of T1D, such as diet, genome, and intestinal microbiota. The gastrointestinal (GI) tract harbors a complex and dynamic population...

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Bibliographic Details
Published in:International journal of molecular sciences 2018-03, Vol.19 (4), p.995
Main Authors: Han, Hui, Li, Yuying, Fang, Jun, Liu, Gang, Yin, Jie, Li, Tiejun, Yin, Yulong
Format: Article
Language:English
Subjects:
Animals
Diabetes Mellitus, Type 1 - epidemiology
Diabetes Mellitus, Type 1 - immunology
Diabetes Mellitus, Type 1 - microbiology
diet
Diet - adverse effects
Dysbiosis - complications
Dysbiosis - etiology
Dysbiosis - immunology
Gastrointestinal Microbiome - immunology
gut microbiota
Homeostasis
hormones
Humans
immune response
Review
type 1 diabetes
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Summary:Recently, the onset of type 1 diabetes (T1D) has increased rapidly and became a major public health concern worldwide. Various factors are associated with the development of T1D, such as diet, genome, and intestinal microbiota. The gastrointestinal (GI) tract harbors a complex and dynamic population of microorganisms, the gut microbiota, which exert a marked influence on the host homeostasis and metabolic diseases. Recent evidence shows that altered gut bacterial composition (dysbiosis) is highly associated with the pathogenesis of insulin dysfunction and T1D and, thus, targeting gut microbiota may serve as a therapeutic potential for T1D patients. In this study, we updated the effect of gut microbiota on T1D and potential mechanisms were discussed.
ISSN:1422-0067
1422-0067
DOI:10.3390/ijms19040995