Ultrasonic or Microwave Modified Continuous Flow Chemistry for the Synthesis of Tetrahydrocannabinol: Observing Effects of Various Solvents and Acids

Synthesizing tetrahydrocannabinol is a lengthy process with minimal yields and little applicability on an industrial scale. To close the gap between bench chemistry and industry process chemistry, this paper introduces a small-scale flow chemistry method that utilizes a microwave or ultrasonic mediu...

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Bibliographic Details
Published in:ACS omega 2024-03, Vol.9 (11), p.13191-13199
Main Authors: Ramirez, Giovanni A., Tesfatsion, Tesfay T., Docampo-Palacios, Maite L., Cruces, Ivan, Hellmann, Adam J., Okhovat, Alex, Pittiglio, Monica K., Ray, Kyle P., Cruces, Westley
Format: Article
Language:English
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Summary:Synthesizing tetrahydrocannabinol is a lengthy process with minimal yields and little applicability on an industrial scale. To close the gap between bench chemistry and industry process chemistry, this paper introduces a small-scale flow chemistry method that utilizes a microwave or ultrasonic medium to produce major tetrahydrocannabinol isomers. This process produces excellent yields and minimal side products, which leads to more efficient large-scale production of the desired cannabinoids.
ISSN:2470-1343
2470-1343
DOI:10.1021/acsomega.3c09794