Caffeine preserves quiet sleep in preterm neonates

Caffeine is widely used in preterm neonates suffering from apnea of prematurity (AOP), and it has become one of the most frequently prescribed medications in neonatal intensive care units. Goal of this study is to investigate how caffeine citrate treatment affects sleep‐wake behavior in preterm neon...

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Published in:Pharmacology research & perspectives 2020-06, Vol.8 (3), p.e00596-n/a
Main Authors: Koch, Gilbert, Schönfeld, Natalie, Jost, Kerstin, Atkinson, Andrew, Schulzke, Sven M., Pfister, Marc, Datta, Alexandre N.
Format: Article
Language:English
Subjects:
Adenosine
apnea of prematurity
Behavior
Birth weight
Caffeine
Caffeine - administration & dosage
Caffeine - pharmacokinetics
Caffeine - pharmacology
Central Nervous System Stimulants - administration & dosage
Central Nervous System Stimulants - pharmacokinetics
Central Nervous System Stimulants - pharmacology
Citrates - administration & dosage
Citrates - pharmacokinetics
Citrates - pharmacology
Eye movements
Female
Gestational age
Humans
Infant, Newborn
Infant, Premature
Intensive care
Male
Metabolism
Models, Biological
Original
Pharmacokinetics
Pharmacology
Premature birth
preterm neonates
Respiration
Sleep
Sleep - drug effects
Wakefulness - drug effects
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Pfister, Marc
Datta, Alexandre N.
description Caffeine is widely used in preterm neonates suffering from apnea of prematurity (AOP), and it has become one of the most frequently prescribed medications in neonatal intensive care units. Goal of this study is to investigate how caffeine citrate treatment affects sleep‐wake behavior in preterm neonates. The observational study consists of 64 preterm neonates during their first 5 days of life with gestational age (GA)
doi_str_mv 10.1002/prp2.596
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Goal of this study is to investigate how caffeine citrate treatment affects sleep‐wake behavior in preterm neonates. The observational study consists of 64 preterm neonates during their first 5 days of life with gestational age (GA) &lt;32 weeks or very low birthweight of &lt; 1500 g. A total of 52 patients treated with caffeine citrate and 12 patients without caffeine citrate were included. Sleep‐wake behavior was scored in three stages: active sleep, quiet sleep, and wakefulness. Individual caffeine concentration of every neonate was simulated with a pharmacokinetic model. In neonates with GA ≥ 28 weeks, wakefulness increased and active sleep decreased with increasing caffeine concentrations, whereas quiet sleep remained unchanged. In neonates with GA &lt; 28 weeks, no clear caffeine effects on sleep‐wake behavior could be demonstrated. 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subjects Adenosine
apnea of prematurity
Behavior
Birth weight
Caffeine
Caffeine - administration & dosage
Caffeine - pharmacokinetics
Caffeine - pharmacology
Central Nervous System Stimulants - administration & dosage
Central Nervous System Stimulants - pharmacokinetics
Central Nervous System Stimulants - pharmacology
Citrates - administration & dosage
Citrates - pharmacokinetics
Citrates - pharmacology
Eye movements
Female
Gestational age
Humans
Infant, Newborn
Infant, Premature
Intensive care
Male
Metabolism
Models, Biological
Original
Pharmacokinetics
Pharmacology
Premature birth
preterm neonates
Respiration
Sleep
Sleep - drug effects
Wakefulness - drug effects
title Caffeine preserves quiet sleep in preterm neonates
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