The Effect of Prebiotic Supplements on the Gastrointestinal Microbiota and Associated Health Parameters in Pigs

• Published in: Animals (Basel) 2023-09, Vol.13 (19), p.3012
• Main Authors: Kiernan, Dillon P, O'Doherty, John V, Sweeney, Torres
• Format: Article
• Language: English
• Subjects: antimicrobial resistance; Bacteria; Carbohydrates; Diet; Dietary fiber; Drug resistance in microorganisms; Ecosystems; Enzymes; Fatty acids; Fermentation; Gastrointestinal system; gut health; Health aspects; Hogs; intestinal dysfunction; Metabolites; Microbiota; Microbiota (Symbiotic organisms); Microorganisms; pathogen infection; Pork industry; post-weaning; Prebiotics; Probiotics; Review; Swine; Weaning
• ISSN: 2076-2615; 2076-2615
• DOI: 10.3390/ani13193012

Establishing a balanced and diverse microbiota in the GIT of pigs is crucial for optimizing health and performance throughout the production cycle. The post-weaning period is a critical phase, as it is often associated with dysbiosis, intestinal dysfunction and poor performance. Traditionally, intestinal dysfunctions associated with weaning have been alleviated using antibiotics and/or antimicrobials. However, increasing concerns regarding the prevalence of antimicrobial-resistant bacteria has prompted an industry-wide drive towards identifying natural sustainable dietary alternatives. Modulating the microbiota through dietary intervention can improve animal health by increasing the production of health-promoting metabolites associated with the improved microbiota, while limiting the establishment and proliferation of pathogenic bacteria. Prebiotics are a class of bioactive compounds that resist digestion by gastrointestinal enzymes, but which can still be utilized by beneficial microbes within the GIT. Prebiotics are a substrate for these beneficial microbes and therefore enhance their proliferation and abundance, leading to the increased production of health-promoting metabolites and suppression of pathogenic proliferation in the GIT. There are a vast range of prebiotics, including carbohydrates such as non-digestible oligosaccharides, beta-glucans, resistant starch, and inulin. Furthermore, the definition of a prebiotic has recently expanded to include novel prebiotics such as peptides and amino acids. A novel class of -biotics, referred to as "stimbiotics", was recently suggested. This bioactive group has microbiota-modulating capabilities and promotes increases in short-chain fatty acid (SCFA) production in a disproportionally greater manner than if they were merely substrates for bacterial fermentation. The aim of this review is to characterize the different prebiotics, detail the current understating of stimbiotics, and outline how supplementation to pigs at different stages of development and production can potentially modulate the GIT microbiota and subsequently improve the health and performance of animals.