Key Genetic Components of Fibrosis in Diabetic Nephropathy: An Updated Systematic Review and Meta-Analysis

Renal fibrosis (RF) constitutes the common end-point of all kinds of chronic kidney disease (CKD), regardless of the initial cause of disease. The aim of the present study was to identify the key players of fibrosis in the context of diabetic nephropathy (DN). A systematic review and meta-analysis o...

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Bibliographic Details
Published in:International journal of molecular sciences 2022-12, Vol.23 (23), p.15331
Main Authors: Tziastoudi, Maria, Theoharides, Theoharis C, Nikolaou, Evdokia, Efthymiadi, Maria, Eleftheriadis, Theodoros, Stefanidis, Ioannis
Format: Article
Language:English
Subjects:
Cytokines
Diabetes
Diabetes Mellitus
Diabetic Nephropathies - genetics
Diabetic nephropathy
Diabetic retinopathy
Encyclopedias
Fibrosis
Genes
Genetic analysis
Genetic Association Studies
Genomes
Genotype & phenotype
Growth factors
Humans
IL-1β
Insulin-like growth factor II
Interleukin 10
Interleukin 6
Kidney diseases
Literature reviews
Meta-analysis
Nephropathy
Players
Polymorphism
renal fibrosis
Renal Insufficiency, Chronic
Review
Signal Transduction
Systematic review
Transforming growth factor-b1
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Summary:Renal fibrosis (RF) constitutes the common end-point of all kinds of chronic kidney disease (CKD), regardless of the initial cause of disease. The aim of the present study was to identify the key players of fibrosis in the context of diabetic nephropathy (DN). A systematic review and meta-analysis of all available genetic association studies regarding the genes that are included in signaling pathways related to RF were performed. The evaluated studies were published in English and they were included in PubMed and the GWAS Catalog. After an extensive literature review and search of the Kyoto Encyclopedia of Genes and Genomes (KEGG) database, eight signaling pathways related to RF were selected and all available genetic association studies of these genes were meta-analyzed. , , , , , , , , , , , , , and were highlighted as the key genetic components driving the fibrosis process in DN. The present systematic review and meta-analysis indicate, as key players of fibrosis in DN, sixteen genes. However, the results should be interpreted with caution because the number of studies was relatively small.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms232315331