Assessing Plasmonic Nanoprobes in Electromagnetic Field Enhancement for SERS Detection of Biomarkers

The exploration of the plasmonic field enhancement of nanoprobes consisting of gold and magnetic core@gold shell nanoparticles has found increasing application for the development of surface-enhanced Raman spectroscopy (SERS)-based biosensors. The understanding of factors controlling the electromagn...

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Bibliographic Details
Published in:Sensors (Basel, Switzerland) Switzerland), 2021-12, Vol.21 (24), p.8345
Main Authors: Cheng, Han-Wen, Xue, Shu-Yan, Li, Jing, Gordon, Justine S, Wang, Shan, Filippone, Nina R, Ngo, Quang Minh, Zhong, Chuan-Jian
Format: Article
Language:English
Subjects:
Antibodies
Antigens
Biomarkers
Biosensors
Cancer
cancer biomarker
Design optimization
electromagnetic field enhancement
Electromagnetic Fields
Electromagnetism
Epidermal growth factor
Gold
gold nanoparticles
Immunoassay
Magnetic cores
magnetic core–shell nanoparticles
Metal Nanoparticles
Nanomaterials
Nanoparticles
plasmonic nanoprobes
Plasmonics
Proteins
Raman spectroscopy
SERS detection
Simulation
Spectrum Analysis, Raman
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Summary:The exploration of the plasmonic field enhancement of nanoprobes consisting of gold and magnetic core@gold shell nanoparticles has found increasing application for the development of surface-enhanced Raman spectroscopy (SERS)-based biosensors. The understanding of factors controlling the electromagnetic field enhancement, as a result of the plasmonic field enhancement of the nanoprobes in SERS biosensing applications, is critical for the design and preparation of the optimal nanoprobes. This report describes findings from theoretical calculations of the electromagnetic field intensity of dimer models of gold and magnetic core@gold shell nanoparticles in immunoassay SERS detection of biomarkers. The electromagnetic field intensities for a series of dimeric nanoprobes with antibody-antigen-antibody binding defined interparticle distances were examined in terms of nanoparticle sizes, core-shell sizes, and interparticle spacing. The results reveal that the electromagnetic field enhancement not only depended on the nanoparticle size and the relative core size and shell thicknesses of the magnetic core@shell nanoparticles but also strongly on the interparticle spacing. Some of the dependencies are also compared with experimental data from SERS detection of selected cancer biomarkers, showing good agreement. The findings have implications for the design and optimization of functional nanoprobes for SERS-based biosensors.
ISSN:1424-8220
1424-8220
DOI:10.3390/s21248345