Four New Limonoids from the Barks of Toona ciliata

Four new limonoids, toonayunnanaes F − I ( 1  −  4 ), and six known compounds ( 5  −  10 ) were isolated from the barks of Toona ciliata . Their structures were elucidated by thoroughly analyzing of NMR and HRMS data, and single-crystal X-ray diffraction of 1 . The oxetane ring moiety in 1 was rare...

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Bibliographic Details
Published in:Natural products and bioprospecting 2021-02, Vol.11 (1), p.81-86
Main Authors: Zhang, Pan-Pan, Bu, Yun-Ge, Xue, Shang, Cui, Zhi-Rong, Tang, Peng-Fei, Luo, Jun, Kong, Ling-Yi
Format: Article
Language:English
Subjects:
Biomedical and Life Sciences
Bioorganic Chemistry
Crystals
Food Science
Life Sciences
Limonoids
Lipopolysaccharides
Macrophages
Medicinal Chemistry
Meliaceae
Natural products
Nitric oxide
NMR
NO inhibitory effects
Nuclear magnetic resonance
Original
Original Article
Pharmacology/Toxicology
Plant Biochemistry
Plant Sciences
Single crystals
Toona ciliata
Toona ciliate
X-ray diffraction
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Summary:Four new limonoids, toonayunnanaes F − I ( 1  −  4 ), and six known compounds ( 5  −  10 ) were isolated from the barks of Toona ciliata . Their structures were elucidated by thoroughly analyzing of NMR and HRMS data, and single-crystal X-ray diffraction of 1 . The oxetane ring moiety in 1 was rare in limonoids and other natural products. Compound 1 showed nitric oxide (NO) inhibitory effect with an IC 50 38.45 ± 0.41 µM in lipopolysaccharide (LPS)-activated RAW 264.7 macrophages. Graphic Abstract
ISSN:2192-2195
2192-2209
DOI:10.1007/s13659-020-00274-w