Noninvasive Evaluation of Liver Fibrosis in a Sample of Putative Inactive HBV Carriers in Rome, Italy

Background. Noninvasive methods are useful for investigating patients with chronic HBV infection. The severity of liver disease in inactive HBsAg carriers can be noninvasively assessed by transient elastography (TE) alone or in association with biochemical markers of fibrosis. Objectives. The study...

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Published in:The Canadian journal of infectious diseases & medical microbiology 2021-08, Vol.2021, p.3068690-7
Main Authors: Delle Monache, Marco, Petrelli, Alessio, Rossi, Alessandra, Cecere, Roberto, Mirisola, Concetta, Costanzo, Gianfranco, Francia, Chiara, Cerini, Federica, Cavani, Andrea, Nosotti, Lorenzo
Format: Article
Language:English
Subjects:
Age
Analysis
Antiviral agents
Biochemical markers
Biochemistry
Biopsy
Chronic infection
Demographic variables
Deoxyribonucleic acid
Development and progression
DNA
Evaluation
Fibrosis
Genetic aspects
Health aspects
Hepatitis B
Hepatitis B surface antigen
Hepatitis B virus
Infection
Infections
Infectious diseases
Liver
Liver diseases
Medical research
Medicine, Experimental
Noninvasive evaluation
Patients
Performance evaluation
Physiological aspects
Population
Standard deviation
Statistical analysis
Stiffness
Variables
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Summary:Background. Noninvasive methods are useful for investigating patients with chronic HBV infection. The severity of liver disease in inactive HBsAg carriers can be noninvasively assessed by transient elastography (TE) alone or in association with biochemical markers of fibrosis. Objectives. The study evaluates the effectiveness of the TE compared to common fibrosis scores (FSs), APRI, Forns Index, and FIB4, for identifying significant fibrosis in Italian and foreigner HBsAg carriers. To investigate the risk of progression of the liver disease, liver stiffness (LS) and HBV-DNA were monitored over time. Methods. Viral load, biochemical parameters, and LS have been retrospectively evaluated in 125 putative inactive HBV carriers, who visited two outpatient departments (Colleferro Hospital and INMP) from 01/03/2014 to 31/12/2019. Differences in clinical, biochemical, and demographic variables between Italians and foreigners were analyzed. 66 of 125 patients were followed up for 24 months by monitoring liver stiffness and HBV-DNA. Results. Mean overall LS was 5.55 ± 1.92 kPa; 18 (14.4%) patients had a LS ≥7.5 kPa. Mean of APRI, Forns, and FIB4 was 0.29 ± 0.11, 4.15 ± 1.63, and 1.16 ± 0.59, respectively. FS did not differ between the patients with LS 
ISSN:1712-9532
1918-1493
DOI:10.1155/2021/3068690