Association between Cognitive Function and Depression with Human T-Cell Lymphotropic Virus 1 Seropositivity and Serointensity in UK Adults

Several viral, bacterial, and parasitic diseases have been associated with cognitive function and neuropsychiatric outcomes in humans, including human T-cell lymphotropic virus 1 (HTLV-1). In this study, we sought to further generalize previously reported associations of cognitive function and depre...

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Bibliographic Details
Published in:Pathogens (Basel) 2021-10, Vol.10 (11), p.1409
Main Authors: Erickson, Lance D., Hedges, Dawson W., Brown, Bruce L., Embley, Bradley, Gale, Shawn D.
Format: Article
Language:English
Subjects:
Adults
Alzheimer's disease
Antibodies
Anxiety
Asymptomatic
Biobanks
Chemokines
cognition
Cognition & reasoning
Cognitive ability
Cognitive tasks
Cytokines
Dementia
depression
Educational attainment
Executive function
High income
HTLV-1
human T-cell lymphotropic virus 1
Infectious diseases
Lymphocytes T
Matching
Mental disorders
Middle age
Parasitic diseases
Reasoning
Regression analysis
Regression models
Sample size
UK Biobank
Viruses
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Summary:Several viral, bacterial, and parasitic diseases have been associated with cognitive function and neuropsychiatric outcomes in humans, including human T-cell lymphotropic virus 1 (HTLV-1). In this study, we sought to further generalize previously reported associations of cognitive function and depression with HTLV-1 seropositivity and serointensity using a community-based sample of adults aged approximately 40 to 70 years (mean = 55.3 years) from the United Kingdom. In this sample, the results of adjusted linear regression models showed no associations of HTLV-1 seropositivity or serointensity with reasoning, pairs-matching, or reaction-time cognitive tasks or with depression. In addition, neither age, sex, educational attainment, nor income moderated associations of HTLV-1 seropositivity or serointensity with cognitive function or depression. In this middle-aged to older middle-aged adult community sample, HTLV-1 seropositivity and serointensity do not appear to be associated with reasoning, pairs-matching, and reaction-time tasks or with depression.
ISSN:2076-0817
2076-0817
DOI:10.3390/pathogens10111409